Luna Expedito, Figueiredo Gerusa, Levi José, Campos Sérgio, Felix Alvina, Souza Nathalia, Figueiredo Walter, Costa Angela, Cardoso Maria, Pannuti Claudio
Faculdade de Medicina/ Instituto de Medicina Tropical, Universidade de São Paulo, São Paulo, Brazil.
Serviço Especial de Saúde de Araraquara, Universidade de São Paulo, Araraquara, Brazil.
Data Brief. 2020 Feb 8;29:105266. doi: 10.1016/j.dib.2020.105266. eCollection 2020 Apr.
Data from the routine surveillance systems have been extensively used to estimate the incidence of dengue. However, routine surveillance data frequently underestimate the diseases' incidence. Underreporting of dengue cases is related to the varying spectrum of its clinical presentation, with a large proportion of mild and asymptomatic infections, to its unspecific signs and symptoms, to the limitations of access to health care, and to the performance of the surveillance system itself [1-3]. In order to obtain accurate figures on dengue incidence, a cohort of children and adolescents was set up and followed during four years. The incidence of reported cases was used as a reference for the sample size calculation, which was stratified by age groups. A two-stage procedure was used to select the participants: census tracts were randomly selected, and within each one, a pre-determined number of children of each age group was randomly selected. The parents or legal guardians of the participating children and adolescents provided a written informed consent. In the first home visit, they responded to a questionnaire containing data on socio-demographic characteristics, housing, access to water, sewage, and garbage collection. Also, during the first visit a blood sample of the participating child/adolescent was collected for dengue baseline serology. Beginning in the week after the enrolment, the parent or legal guardian that was designated in the first visit received weekly phone calls for fever surveillance. If the child/adolescent had fever during the week, a nurse was dispatched to the family's home to collect more detailed data on the fever episode and collect a blood sample for dengue diagnosis (IgG, IgM, NS1 and PCR). If the dengue diagnosis was confirmed, a medical appointment was scheduled, and another blood sample for confirmatory tests was collected. It was also agreed that in every anniversary of their participation, they would receive another visit for a blood collection for dengue serology, regardless if they had a fever episode or a confirmed dengue diagnosis during the previous year. This article contains the description of the cohort's dataset. It is associated with the article published in Acta Tropica, under the title "A cohort study to assess the incidence of dengue, Brazil, 2014-2018" [4]. The associated article focused on the seroprevalence and incidence of dengue, and explored some associations between both outcomes and some explanatory variables.
常规监测系统的数据已被广泛用于估计登革热的发病率。然而，常规监测数据常常低估了该疾病的发病率。登革热病例报告不足与多种因素有关，包括其临床表现的多样性（很大一部分为轻症和无症状感染）、非特异性的体征和症状、获得医疗服务的局限性以及监测系统本身的运行情况[1-3]。为了获得登革热发病率的准确数据，设立了一个儿童和青少年队列，并对其进行了四年的跟踪。报告病例的发病率被用作样本量计算的参考，样本按年龄组分层。采用两阶段程序选择参与者：随机选择普查区，在每个普查区内，随机选择每个年龄组预先确定数量的儿童。参与研究的儿童和青少年的父母或法定监护人提供了书面知情同意书。在首次家访中，他们回答了一份包含社会人口学特征、住房、用水、污水和垃圾收集等数据的问卷。此外，在首次家访期间，采集了参与研究的儿童/青少年的血样用于登革热基线血清学检测。从入组后的第一周开始，首次家访中指定的父母或法定监护人每周会接到关于发热监测的电话。如果儿童/青少年在当周发烧，会派遣一名护士前往其家中收集关于发热发作的更详细数据，并采集血样用于登革热诊断（检测IgG、IgM、NS1和PCR）。如果登革热诊断得到确认，会安排一次医疗预约，并采集另一份血样用于确诊检测。还商定，在他们参与研究的每一周年，无论他们在上一年是否有发热发作或确诊的登革热诊断，都会再次接受家访以采集用于登革热血清学检测的血样。本文包含该队列数据集的描述。它与发表在《热带病学报》上的一篇文章相关，文章标题为“2014 - 2018年巴西评估登革热发病率的队列研究”[4]。相关文章重点关注登革热的血清流行率和发病率，并探讨了这两个结果与一些解释变量之间的一些关联。
