去细胞化细胞外基质水凝胶在再生医学中的研究进展
[Research progress of decellularized extracellular matrix hydrogel in regenerative medicine].
作者信息
Jiang Jingyu, Zhang Chi, Zhang Tingxia, Zhao Jiyuan
机构信息
Key Laboratory of Pathophysiology and Technology Research, Medicine School, Ningbo University, Ningbo, Zhejiang 315211, P.R.China.
Key Laboratory of Pathophysiology and Technology Research, Medicine School, Ningbo University, Ningbo, Zhejiang 315211, P.R.China;Ningbo First Hospital, Ningbo, Zhejiang 315010, P.R.China.
出版信息
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2020 Feb 25;37(1):179-184. doi: 10.7507/1001-5515.201907027.
Decellularized extracellular matrix (dECM) has been widely used as a scaffold for regenerative medicine due to its high biomimetic and excellent biocompatibility. As a functional polymer material with high water content and controlled fluidity, hydrogel is very promising for some minimally invasive surgery in clinical practice. In recent years, with the rapid development of hydrogel theory and technology, dECM hydrogel has gradually become a research hotspot in the field of regenerative medicine. In this paper, the related researches in recent years are reviewed regarding the preparation of dECM hydrogel and its preclinical application. The future clinical use is also prospected.
脱细胞细胞外基质（dECM）因其高度仿生和出色的生物相容性，已被广泛用作再生医学的支架。水凝胶作为一种具有高含水量和可控流动性的功能性高分子材料，在临床实践中的一些微创手术中具有很大的应用前景。近年来，随着水凝胶理论和技术的快速发展，dECM水凝胶逐渐成为再生医学领域的研究热点。本文综述了近年来关于dECM水凝胶制备及其临床前应用的相关研究，并对其未来的临床应用进行了展望。
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