From the Department of Radiology, German Cancer Research Center, Heidelberg.
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen.
Invest Radiol. 2020 Jun;55(6):381-386. doi: 10.1097/RLI.0000000000000650.
Quantitative T1 relaxometry is the benchmark in imaging potential gadolinium deposition and known to be superior to semiquantitative signal intensity ratio analyses. However, T1 relaxometry studies are rare, commonly limited to a few target structures, and reported results are inconsistent.We systematically investigated quantitative T1 relaxation times (qT1) of a variety of brain nuclei after serial application of gadobutrol.
Retrospectively, qT1 measurements were performed in a patient cohort with a mean number of 11 gadobutrol applications (n = 46) and compared with a control group with no prior gadolinium-based contrast agent administration (n = 48). The following target structures were evaluated: dentate nucleus, globus pallidus, thalamus, hippocampus, putamen, caudate, amygdala, and different white matter areas. Subsequently, multivariate regression analysis with adjustment for age, presence of brain metastases and previous cerebral radiotherapy was performed.
No assessed site revealed a significant correlation between qT1 and number of gadobutrol administrations in multivariate regression analysis. However, a significant negative correlation between qT1 and age was found for the globus pallidus as well as anterior and lateral thalamus (P < 0.05 each).
No T1 relaxation time shortening due to gadobutrol injection was found in any of the assessed brain structures after serial administration of 11 doses of gadobutrol.
定量 T1 弛豫时间是评估潜在钆沉积的基准，优于半定量信号强度比分析。然而，T1 弛豫时间研究很少，通常局限于少数目标结构，并且报告的结果不一致。我们系统地研究了连续应用钆布醇后各种脑核的定量 T1 弛豫时间（qT1）。
回顾性地，对一组平均接受 11 次钆布醇应用（n=46）的患者队列进行 qT1 测量，并与未接受过基于钆的造影剂治疗的对照组（n=48）进行比较。评估了以下目标结构：齿状核、苍白球、丘脑、海马体、壳核、尾状核、杏仁核和不同的白质区域。随后，进行了调整年龄、脑转移和以前脑放射治疗的多变量回归分析。
多变量回归分析显示，任何评估部位的 qT1 与钆布醇给药次数之间均无显著相关性。然而，在多变量回归分析中，发现苍白球以及前侧丘脑的 qT1 与年龄呈显著负相关（P<0.05 各）。
在连续给予 11 剂钆布醇后，在任何评估的脑结构中均未发现由于钆布醇注射导致的 T1 弛豫时间缩短。
