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槲皮素在乳腺癌中的抗癌特性研究综述。

A review on anti-cancer properties of Quercetin in breast cancer.

机构信息

Department of Anatomical sciences, Faculty of medicine, Tabriz University of medical sciences, Tabriz, Iran.

Molecular Medicine Research Center, Tabriz University of medical sciences, Tabriz, Iran.

出版信息

Life Sci. 2020 May 1;248:117463. doi: 10.1016/j.lfs.2020.117463. Epub 2020 Feb 22.

Abstract

Breast cancer is one of the well-known malignant tumors among women. In spite of attempts to classifying breast cancer according to its histological and molecular properties, it is almost considered as a dilemma in treatment. Nowadays, public and medical attentions have primary focused on foods with anti-cancer properties to alleviate the cancer problems. Flavonoid components such as Quercetin (Qu) as dietary substances with high attention of ordinary people might provide potential of alternative or complementary medicine in breast cancer. With regard to the wide range of health benefits of Qu, researchers have been generally convinced to bring Qu as natural compounds in cancer therapy. Moreover, the high cost of standard cancer treatments and the failure of most conventional treatments have led the medical community to pursue cost-effective prevention and treatment. As a result, a great deal of concentration is attracted to diet/cancer reciprocal action. Therefore, this review study has aimed to identify what has revealed the critical properties of Qu such as anti-inflammatory, anti-oxidant, and even its effect on proliferation, angiogenesis, or apoptosis that are considered as anti-tumor property to enhance breast cancer treatment.

摘要

乳腺癌是女性中较为知名的恶性肿瘤之一。尽管人们试图根据其组织学和分子特性对乳腺癌进行分类,但在治疗方面仍几乎被视为一个难题。如今,公众和医学界主要关注具有抗癌特性的食物,以缓解癌症问题。黄酮类化合物如槲皮素 (Qu) 作为人们普遍关注的膳食物质,可能为乳腺癌提供替代或补充药物的潜力。鉴于 Qu 具有广泛的健康益处,研究人员普遍认为将 Qu 作为癌症治疗中的天然化合物。此外,标准癌症治疗的高昂成本和大多数常规治疗的失败导致医学界寻求具有成本效益的预防和治疗方法。因此,人们对饮食/癌症相互作用的研究产生了浓厚的兴趣。因此,本综述研究旨在确定 Qu 的关键特性,如抗炎、抗氧化,甚至其对增殖、血管生成或细胞凋亡的影响,这些特性被认为是抗肿瘤特性,可增强乳腺癌的治疗效果。

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