Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 PA, USA; Biochemistry & Molecular Biophysics Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 PA, USA.
Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 PA, USA; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, 19104 PA, USA.
Curr Opin Cell Biol. 2020 Apr;63:144-153. doi: 10.1016/j.ceb.2020.01.013. Epub 2020 Feb 22.
Recent years have seen a great expansion in our knowledge of the roles that metabolites play in cellular signaling. Structural data have provided crucial insights into mechanisms through which amino acids are sensed. New nutrient-coupled protein and RNA modifications have been identified and characterized. A growing list of functions has been ascribed to metabolic regulation of modifications such as acetylation, methylation, and glycosylation. A current challenge lies in developing an integrated understanding of the roles that metabolic signaling mechanisms play in physiology and disease, which will inform the design of strategies to target such mechanisms. In this brief article, we review recent advances in metabolic signaling through post-translational modification during cancer progression, to provide a framework for understanding signaling roles of metabolites in the context of cancer biology and illuminate areas for future investigation.
近年来，我们对代谢物在细胞信号转导中所扮演的角色有了更深入的了解。结构数据为我们提供了关于氨基酸感知机制的关键见解。新的营养偶联蛋白和 RNA 修饰已被鉴定和表征。越来越多的功能被归因于代谢对乙酰化、甲基化和糖基化等修饰的调节。当前的挑战在于发展对代谢信号机制在生理和疾病中的作用的综合理解，这将为设计靶向这些机制的策略提供信息。在这篇简短的文章中，我们综述了癌症进展过程中通过翻译后修饰进行代谢信号转导的最新进展，为理解代谢物在癌症生物学背景下的信号作用提供了一个框架，并阐明了未来研究的领域。
