代谢酶和代谢物在癌症中的兼职功能。
Moonlighting functions of metabolic enzymes and metabolites in cancer.
机构信息
Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.
Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510080, China; Center for Precision Medicine, Sun Yat-sen University, Guangzhou 510080, China.
出版信息
Mol Cell. 2021 Sep 16;81(18):3760-3774. doi: 10.1016/j.molcel.2021.08.031.
The growing field of tumor metabolism has greatly expanded our knowledge of metabolic reprogramming in cancer. Apart from their established roles, various metabolic enzymes and metabolites harbor non-canonical ("moonlighting") functions to support malignant transformation. In this article, we intend to review the current understanding of moonlighting functions of metabolic enzymes and related metabolites broadly existing in cancer cells by dissecting each major metabolic pathway and its regulation of cellular behaviors. Understanding these non-canonical functions may broaden the horizon of the cancer metabolism field and uncover novel therapeutic vulnerabilities in cancer.
肿瘤代谢领域的不断发展极大地扩展了我们对癌症代谢重编程的认识。除了它们的既定作用外，各种代谢酶和代谢物还具有支持恶性转化的非典型（“兼职”）功能。在本文中，我们旨在通过剖析每个主要代谢途径及其对细胞行为的调节，综述代谢酶和相关代谢物在癌细胞中广泛存在的兼职功能的现有认识。了解这些非典型功能可能会拓宽癌症代谢领域的视野，并揭示癌症的新治疗弱点。
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