Su Chun-Lang, Tantoh Disline Manli, Chou Ying-Hsiang, Wang Lee, Ho Chien-Chang, Chen Pei-Hsin, Lee Kuan-Jung, Nfor Oswald Ndi, Hsu Shu-Yi, Liang Wen-Miin, Liaw Yung-Po
Department of Public Health and Institute of Public Health, Chung Shan Medical University, Taichung 40201, Taiwan.
School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
Cancers (Basel). 2020 Feb 21;12(2):504. doi: 10.3390/cancers12020504.
Increased ventilation during exercise in polluted areas could trigger airway inflammation. We evaluated blood DNA methylation of the SOX2-promoter region in relation to exercise and PM in Taiwanese adults. Data of 948 participants aged 30-70 years were retrieved from the Taiwan Biobank Database (2008-2015) and the Air Quality Monitoring Database (2006-2011). PM was positively associated with SOX2-promoter methylation (β = 0.000216; p < 0.0001). The interaction between PM and exercise on SOX2-promoter methylation was significant (p = 0.0146). After stratification by exercise habits, PM was positively associated with SOX2 methylation in only individuals who did regular exercise (β = 0.0003490; < 0.0001). After stratification by exercise habits and residential areas, SOX2-promoter methylation levels in those who lived in the southern area were higher for both the regular exercise (β = 0.00272; = 0.0172) and no regular exercise groups (β = 0.002610 and = 0.0162). SOX2-promoter methylation levels in those who lived in the northern area and did regular exercise were lower; β = -0.00314 ( = 0.0036). In conclusion, PM was positively associated with SOX2-promoter methylation in participants who did regular exercise. Living in the southern area was positively associated with SOX2-promoter methylation regardless of exercise habits.
在污染地区运动期间通气增加可能引发气道炎症。我们评估了台湾成年人中与运动和颗粒物（PM）相关的SOX2启动子区域的血液DNA甲基化情况。从台湾生物银行数据库（2008 - 2015年）和空气质量监测数据库（2006 - 2011年）中检索了948名年龄在30 - 70岁参与者的数据。PM与SOX2启动子甲基化呈正相关（β = 0.000216；p < 0.0001）。PM与运动对SOX2启动子甲基化的相互作用显著（p = 0.0146）。按运动习惯分层后，仅在经常运动的个体中PM与SOX2甲基化呈正相关（β = 0.0003490；< 0.0001）。按运动习惯和居住地区分层后，居住在南部地区的经常运动组（β = 0.00272；= 0.0172）和不经常运动组（β = 0.002610和= 0.0162）的SOX2启动子甲基化水平均较高。居住在北部地区且经常运动的个体的SOX2启动子甲基化水平较低；β = -0.00314（= 0.0036）。总之，在经常运动的参与者中，PM与SOX2启动子甲基化呈正相关。无论运动习惯如何，居住在南部地区与SOX2启动子甲基化呈正相关。
