Chen Xiaojun, Mo Deyun, Gong Manfeng
School of Mechanical and Electronic Engineering, Lingnan normal university, Zhanjiang 524048, China.
Micromachines (Basel). 2020 Feb 21;11(2):224. doi: 10.3390/mi11020224.
Integrated microfluidic systems afford extensive benefits for chemical and biological fields, yet traditional, monolithic methods of microfabrication restrict the design and assembly of truly complex systems. Here, a simple, reconfigurable and high fluid pressure modular microfluidic system is presented. The screw interconnects reversibly assemble each individual microfluidic module together. Screw connector provided leak-free fluidic communication, which could withstand fluid resistances up to 500 kPa between two interconnected microfluidic modules. A sample library of standardized components and connectors manufactured using 3D printing was developed. The capability for modular microfluidic system was demonstrated by generating sodium alginate gel microspheres. This 3D printed modular microfluidic system makes it possible to meet the needs of the end-user, and can be applied to bioassays, material synthesis, and other applications.
集成微流控系统为化学和生物领域带来了诸多益处，然而传统的整体式微加工方法限制了真正复杂系统的设计与组装。在此，我们展示了一种简单、可重构且具有高流体压力的模块化微流控系统。螺旋互连件将各个微流控模块可逆地组装在一起。螺旋连接器提供无泄漏的流体连通，在两个互连的微流控模块之间能够承受高达500 kPa的流体阻力。开发了一个使用3D打印制造的标准化组件和连接器的样本库。通过生成海藻酸钠凝胶微球展示了模块化微流控系统的能力。这种3D打印的模块化微流控系统能够满足终端用户的需求，并可应用于生物测定、材料合成及其他应用。
