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检查使用酒精应对、抑郁症状和感知社会支持在 HIV 和丙型肝炎患者中的作用。

Examination of using alcohol to cope, depressive symptoms, and perceived social support in persons with HIV and Hepatitis C.

机构信息

Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence RI, USA.

Behavioral Medicine and Addictions Research Unit, Butler Hospital, Providence RI, USA.

出版信息

AIDS Care. 2020 Oct;32(10):1238-1245. doi: 10.1080/09540121.2020.1734177. Epub 2020 Feb 25.

DOI:10.1080/09540121.2020.1734177
PMID:32098484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7483592/
Abstract

Depression is common among people living with HIV (PLWH) and some likely turn to alcohol to cope with this emotional distress. Using alcohol to cope is associated with increased alcohol use, persistent longitudinal alcohol use, and alcohol-related problems. This association is particularly concerning among PLWH who are co-infected with Hepatitis C (HCV) because alcohol adds to the damage already caused by HCV. Despite data showing the associated risks of using alcohol to cope, scant research has examined factors that might contribute to coping-based alcohol use in HIV-HCV patients, such as limited social support. Baseline data from a randomized trial of strategies to reduce alcohol use in co-infected HIV and HCV adult patients (n=110) were analyzed. Multiple linear regression models were used to estimate the association between using alcohol to cope, depression, and four aspects of social support, controlling for demographic variables. Results showed that using alcohol to cope was not significantly correlated with social support but was significantly correlated with depressive symptoms. In fact, depressive symptoms and severity of alcohol consumption accounted for nearly 45% of the variance related to coping-based alcohol use. These data highlight the central role of depression in the coping motives-alcohol use relationship among co-infected patients.

摘要

抑郁症在 HIV 感染者(PLWH)中很常见,有些人可能会借助酒精来应对这种情绪困扰。使用酒精来应对会导致酒精使用量增加、持续的纵向酒精使用和与酒精相关的问题。对于同时感染丙型肝炎(HCV)的 PLWH 来说,这种关联尤其令人担忧,因为酒精会加重 HCV 已经造成的损害。尽管有数据显示使用酒精来应对会带来相关风险,但很少有研究探讨可能导致 HIV-HCV 患者基于应对的酒精使用的因素,例如有限的社会支持。对感染 HIV 和 HCV 的成年患者(n=110)减少酒精使用策略的随机试验的基线数据进行了分析。使用多元线性回归模型来估计使用酒精来应对、抑郁和社会支持的四个方面之间的关联,控制了人口统计学变量。结果表明,使用酒精来应对与社会支持没有显著相关性,但与抑郁症状显著相关。事实上,抑郁症状和酒精摄入量的严重程度几乎占与应对相关的酒精使用差异的 45%。这些数据突出了抑郁在合并感染患者的应对动机与酒精使用关系中的核心作用。

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