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2
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An abnormal ProC Global test result is associated with an increased risk of venous thromboembolism independent of test sensitivity for protein C pathway abnormalities.异常的总蛋白C检测结果与静脉血栓栓塞风险增加相关，且独立于蛋白C途径异常的检测敏感性。
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本文引用的文献

1
Incidence and Risk Factors for Venous Thromboembolism Following Hip Arthroscopy: A Population-Based Study.髋关节镜检查后静脉血栓栓塞症的发生率及危险因素：一项基于人群的研究。
Arthroscopy. 2019 Aug;35(8):2380-2384.e1. doi: 10.1016/j.arthro.2019.03.054.
2
Laboratory medicine: health evaluation in elite athletes.检验科医学：精英运动员的健康评估。
Clin Chem Lab Med. 2019 Sep 25;57(10):1450-1473. doi: 10.1515/cclm-2018-1107.
3
Acquired and Genetic Thrombotic Risk Factors in the Athlete.运动员获得性和遗传性血栓形成危险因素。
Semin Thromb Hemost. 2018 Nov;44(8):723-733. doi: 10.1055/s-0038-1673625. Epub 2018 Oct 4.
4
Warfarin anticoagulant therapy: a Southern Italy pharmacogenetics-based dosing model.华法林抗凝治疗：基于意大利南部人群的药物基因组学剂量模型。
PLoS One. 2013 Aug 26;8(8):e71505. doi: 10.1371/journal.pone.0071505. eCollection 2013.
5
Venous thrombosis in athletes.运动员静脉血栓形成。
J Am Acad Orthop Surg. 2013 Feb;21(2):108-17. doi: 10.5435/JAAOS-21-02-108.
6
Unsuspected triggers of venous thromboembolism--trivial or not so trivial?静脉血栓栓塞症未被察觉的触发因素——微不足道还是并非如此？
Semin Thromb Hemost. 2009 Oct;35(7):597-604. doi: 10.1055/s-0029-1242713.
7
Four cases of venous thrombosis in athletes with silent hereditary defects of the protein C system.4例患有蛋白C系统隐性遗传性缺陷的运动员发生静脉血栓形成。
Thromb Haemost. 2005 Aug;94(2):463-4.
8
Acute versus habitual exercise, thrombogenesis and exercise intensity.急性运动与习惯性运动、血栓形成及运动强度
Thromb Haemost. 2004 Mar;91(3):416-9.
9
Exercise-induced activation of coagulation in thrombophilia.易栓症中运动诱导的凝血激活。
J Thromb Haemost. 2003 Jun;1(6):1312-3. doi: 10.1046/j.1538-7836.2003.t01-1-00326.x.
10
Thrombin potential and thrombin generation after exhaustive exercise.力竭运动后的凝血酶潜力和凝血酶生成
Int J Sports Med. 2002 Oct;23(7):500-4. doi: 10.1055/s-2002-35123.

小样本研究中的体力活动与血栓形成倾向风险

Physical Activity and Thrombophilic Risk in a Short Series.

作者信息

Scudiero Olga, Gentile Luca, Ranieri Annaluisa, Coppola Eduardo, Di Micco Pierpaolo, Mazzaccara Cristina, D'alicandro Giovanni, Leggiero Eleonora, Frisso Giulia, Pastore Lucio, Lombardo Barbara

机构信息

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli "Federico II", Napoli, Italia.

CEINGE-Biotecnologie Avanzate, Napoli, Italia.

出版信息

J Blood Med. 2020 Jan 30;11:39-42. doi: 10.2147/JBM.S220566. eCollection 2020.

DOI:10.2147/JBM.S220566
PMID:32099499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6996552/
Abstract

The role of influence on protein C anticoagulant system and PC deficiency-related thrombophilic risk due to strenuous physical exercise is still under discussion. To investigate the modification of the protein C anticoagulant pathway after vigorous exercise, we measured ProC Global assay, a protein C activity dependent clotting time, in 20 healthy subjects before and immediately after maximal treadmill exercise, and at 5, 15, 30 and 60 min in the recovery phase. The most evident change was a shortening of ProC Global clotting time from the average basal value of 123 sec to 84 sec at 30 min in post-exercise. Our study shows that the coagulation unbalance observed after strenuous exercise and with no consequence in healthy individuals with normal PC level, could increase the thrombophilic risk in silent carriers of significant defects of the protein C system and occasionally trigger an episode of deep vein thrombosis.

摘要

剧烈体育锻炼对蛋白C抗凝系统的影响以及与蛋白C缺乏相关的血栓形成风险仍在讨论中。为了研究剧烈运动后蛋白C抗凝途径的变化，我们在20名健康受试者进行最大强度跑步机运动前、运动后即刻以及恢复阶段的5、15、30和60分钟，测量了ProC Global检测，这是一种依赖蛋白C活性的凝血时间。最明显的变化是运动后30分钟时ProC Global凝血时间从平均基础值123秒缩短至84秒。我们的研究表明，剧烈运动后观察到的凝血失衡在蛋白C水平正常的健康个体中无不良后果，但可能会增加蛋白C系统存在严重缺陷的无症状携带者的血栓形成风险，并偶尔引发深静脉血栓形成发作。