Jia Xiaowen, Zhang Rong, Guo Jinzhu, Yue Hua, Liu Qiuxia, Guo Lipei, Zhang Qunchang
Department of Gynecology and Obstetrics, XiDian Group Hospital, Xi'an, Shaanxi 710077, China.
Int J Hypertens. 2020 Jan 21;2020:4154010. doi: 10.1155/2020/4154010. eCollection 2020.
Pregnancy-induced hypertension (PIH) remains a major cause of morbidity and mortality in pregnancy worldwide. This study was designed to study the blood pressure-lowering effect of resveratrol (RES) in a salt-induced hypertensive pregnant rat model.
Forty female Sprague Dawley (SD) rats were randomized into 4 groups: Normal Preg (0.9% salt diet), Normal Preg + RES (0.9% salt diet plus daily oral RES for 4 weeks), Salt Preg (8% salt diet), and Salt Preg + RES (8% salt diet plus daily oral RES for 4 weeks). Noninvasive blood pressure was recorded on gestational days 7 and 14. On the gestational day 19, foetuses were weighed, and blood and urine samples were harvested for electrolytes and biochemical assays.
RES significantly reduced SBP, DBP, and MAP on gestational days 7 and 14 in the Salt Preg + RES group compared to the Salt Preg group (all < 0.05). Compared to the Salt Preg group, the foetal weight, serum NO level, urinary sodium, and 24 hour urine volume were significantly increased in the Salt Preg + RES group (all < 0.05). Compared to the Salt Preg group, the foetal weight, serum NO level, urinary sodium, and 24 hour urine volume were significantly increased in the Salt Preg + RES group (all < 0.05). Compared to the Salt Preg group, the foetal weight, serum NO level, urinary sodium, and 24 hour urine volume were significantly increased in the Salt Preg + RES group (all.
RES decreases blood pressure in a hypertensive pregnant rat model. Increasing sodium excretion and serum nitric oxide level might be, at least part of, the underlying mechanisms.
妊娠高血压（PIH）仍是全球妊娠期间发病和死亡的主要原因。本研究旨在研究白藜芦醇（RES）在盐诱导的高血压妊娠大鼠模型中的降压作用。
40只雌性Sprague Dawley（SD）大鼠随机分为4组：正常妊娠组（0.9%盐饮食）、正常妊娠+RES组（0.9%盐饮食加每日口服RES 4周）、盐诱导妊娠组（8%盐饮食）和盐诱导妊娠+RES组（8%盐饮食加每日口服RES 4周）。在妊娠第7天和第14天记录无创血压。在妊娠第19天，称量胎儿体重，并采集血液和尿液样本进行电解质和生化分析。
与盐诱导妊娠组相比（均P<0.05），盐诱导妊娠+RES组在妊娠第7天和第14天的收缩压、舒张压和平均动脉压显著降低。与盐诱导妊娠组相比，盐诱导妊娠+RES组的胎儿体重、血清一氧化氮水平、尿钠和24小时尿量显著增加（均P<0.05）。与盐诱导妊娠组相比，盐诱导妊娠+RES组的胎儿体重、血清一氧化氮水平、尿钠和24小时尿量显著增加（均P<0.05）。与盐诱导妊娠组相比，盐诱导妊娠+RES组的胎儿体重、血清一氧化氮水平、尿钠和24小时尿量显著增加（均P<0.05）。
RES可降低高血压妊娠大鼠模型的血压。增加钠排泄和血清一氧化氮水平可能至少是其潜在机制的一部分。
