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西咪替丁和维拉帕米对扑热息痛诱导的小鼠肝毒性保护作用的比较研究

Comparative Study of Protective Effect of Cimetidine and Verapamil on Paracetamol-Induced Hepatotoxicity in Mice.

作者信息

Danish Lubna, Siddiq Riffat, Jahan Sarwat, Taneez Mehwish, Khan Manzoor, Sandhu Marva

机构信息

Sulaiman Bin Abdullah Aba Al-Khail Centre for Interdisciplinary Research in Basic Sciences (CIRBS), International Islamic University Islamabad (IIUI), Islamabad, Pakistan.

Department of Maxillofacial Surgery, Rehman College of Dentistry, Peshawar, Pakistan.

出版信息

Int J Hepatol. 2020 Jan 23;2020:9185361. doi: 10.1155/2020/9185361. eCollection 2020.

DOI:10.1155/2020/9185361
PMID:32099681
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6998752/
Abstract

Paracetamol, chemically known as acetaminophen, if taken in higher doses has hepatotoxic potential. Cimetidine by inhibiting the cytochromal enzymes and reducing the production of the toxic metabolite can reduce the hepatotoxic potential while Verapamil can act as a hepatoprotective by maintaining calcium homeostasis. The present study was conducted to study the hepatoprotective activity of Cimetidine and Verapamil against the toxicity induced by paracetamol. In addition to the group receiving only distilled water or 300 mg/kg paracetamol additional groups were added treated with 150 mg/kg Cimetidine and Verapamil alone or both. The Liver function tests and histopathology revealed hepatotoxicity in the group receiving paracetamol (PCM) while normal parameters were observed in the groups receiving Cimetidine and Verapamil. Our results strongly suggested that Cimetidine and Verapamil possess hepatoprotective potential against paracetamol induced hepatotoxicity.

摘要

对乙酰氨基酚，化学名称为醋氨酚，若大剂量服用具有肝毒性。西咪替丁通过抑制细胞色素酶并减少有毒代谢物的产生，可降低肝毒性，而维拉帕米可通过维持钙稳态起到肝脏保护作用。本研究旨在探讨西咪替丁和维拉帕米对乙酰氨基酚诱导的毒性的肝脏保护活性。除了仅接受蒸馏水或300毫克/千克对乙酰氨基酚的组外，还添加了单独用150毫克/千克西咪替丁和维拉帕米或两者治疗的额外组。肝功能测试和组织病理学显示，接受对乙酰氨基酚（PCM）的组出现肝毒性，而接受西咪替丁和维拉帕米的组观察到正常参数。我们的结果强烈表明，西咪替丁和维拉帕米对乙酰氨基酚诱导的肝毒性具有肝脏保护潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/3aff76840447/IJH2020-9185361.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/349c3884034a/IJH2020-9185361.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/556f22ebaee6/IJH2020-9185361.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/ade2b6ef750a/IJH2020-9185361.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/9352ace9d055/IJH2020-9185361.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/563bbf095740/IJH2020-9185361.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/3aff76840447/IJH2020-9185361.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/349c3884034a/IJH2020-9185361.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/556f22ebaee6/IJH2020-9185361.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/ade2b6ef750a/IJH2020-9185361.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/9352ace9d055/IJH2020-9185361.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/563bbf095740/IJH2020-9185361.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3cc/6998752/3aff76840447/IJH2020-9185361.006.jpg

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本文引用的文献

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Pharmaceutics. 2019 Mar 21;11(3):139. doi: 10.3390/pharmaceutics11030139.
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Predictive Performance of Physiologically-Based Pharmacokinetic Models in Predicting Drug-Drug Interactions Involving Enzyme Modulation.基于生理学的药代动力学模型预测涉及酶调节的药物相互作用的预测性能。
Clin Pharmacokinet. 2018 Oct;57(10):1337-1346. doi: 10.1007/s40262-018-0635-8.
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Acetaminophen Relieves Inflammatory Pain through CB Cannabinoid Receptors in the Rostral Ventromedial Medulla.
醋氨酚通过延髓头端腹内侧区的 CB 大麻素受体缓解炎性疼痛。
J Neurosci. 2018 Jan 10;38(2):322-334. doi: 10.1523/JNEUROSCI.1945-17.2017. Epub 2017 Nov 22.
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Are some people at increased risk of paracetamol-induced liver injury? A critical review of the literature.有些人对扑热息痛引起的肝损伤风险更高吗？对相关文献的批判性综述。
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Hepatotoxicity in Rats Induced by Aqueous Extract of Polygoni Multiflori Radix, Root of Related to the Activity Inhibition of CYP1A2 or CYP2E1.何首乌水提取物诱导大鼠肝毒性与CYP1A2或CYP2E1活性抑制有关。
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Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study.CYP2D6基因分型对阿米替林治疗糖尿病周围神经病变疗效的影响：一项初步研究。
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