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结直肠癌继发疑似脉络膜转移的光动力疗法:文献综述

Photodynamic Therapy of Presumed Choroidal Metastasis Secondary to Colorectal Carcinoma: Literature Review.

作者信息

Biccas Neto Laurentino, Pulido José Z, Melo Gustavo B, Lima Luiz H, Rodrigues Eduardo B

机构信息

Ocular Oftalmologia, Vitória, Brazil.

Department of Oncology, Hospital Evangélico, Cachoeiro do Itapemirim, Brazil.

出版信息

Case Rep Ophthalmol Med. 2020 Jan 30;2020:6490535. doi: 10.1155/2020/6490535. eCollection 2020.

DOI:10.1155/2020/6490535
PMID:32099706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7016402/
Abstract

Colorectal cancer may yield metastasis to the choroid. Its management may be challenging, since there is no consensus about treatment. We describe a case of a 70-year-old male with colon cancer who complained of worsening visual acuity of his better-seeing eye to 20/40 secondary to a nonpigmented choroidal mass of medium reflectivity under the inferior temporal arcade and neurosensory foveal detachment. Besides systemic chemotherapy, local treatment with verteporfin photodynamic therapy (vPDT) was performed. After one month, visual acuity improved to 20/25 and subretinal fluid faded. In conclusion, vPDT may be a useful adjuvant treatment modality for choroidal metastasis secondary to colorectal cancer.

摘要

结直肠癌可能会转移至脉络膜。其治疗可能具有挑战性,因为对于治疗尚无共识。我们描述了一例70岁男性结肠癌患者,其较好眼的视力恶化为20/40,原因是颞下弓下方有一个中等反射率的无色素脉络膜肿物以及神经感觉性黄斑脱离。除了全身化疗外,还进行了维替泊芬光动力疗法(vPDT)局部治疗。一个月后,视力提高到20/25,视网膜下液消退。总之,vPDT可能是结直肠癌继发脉络膜转移的一种有用的辅助治疗方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d7/7016402/9ee0de564b5c/CRIOPM2020-6490535.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d7/7016402/56780ca671eb/CRIOPM2020-6490535.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d7/7016402/a1ce6ec2477a/CRIOPM2020-6490535.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d7/7016402/9ee0de564b5c/CRIOPM2020-6490535.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d7/7016402/56780ca671eb/CRIOPM2020-6490535.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d7/7016402/a1ce6ec2477a/CRIOPM2020-6490535.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/22d7/7016402/9ee0de564b5c/CRIOPM2020-6490535.003.jpg

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本文引用的文献

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Choroidal Mucinous Metastatic Adenocarcinoma from the Colon: A Diagnostic Challenge.来自结肠的脉络膜黏液性转移性腺癌:一项诊断挑战。
Ocul Oncol Pathol. 2019 Jan;5(1):66-74. doi: 10.1159/000487598. Epub 2018 Jun 27.
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New concepts in the diagnosis and management of choroidal metastases.脉络膜转移瘤的诊断和治疗新概念。
Prog Retin Eye Res. 2019 Jan;68:144-176. doi: 10.1016/j.preteyeres.2018.09.003. Epub 2018 Sep 19.
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Uveal Metastasis: Clinical Features and Survival Outcome of 2214 Tumors in 1111 Patients Based on Primary Tumor Origin.
脉络膜转移作为直肠腺癌的首发表现
Eur J Case Rep Intern Med. 2021 Dec 15;8(12):003059. doi: 10.12890/2021_003059. eCollection 2021.
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Role of Metastasis Suppressor KAI1/CD82 in Different Cancers.转移抑制因子KAI1/CD82在不同癌症中的作用
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葡萄膜转移瘤:基于原发肿瘤起源的1111例患者中2214个肿瘤的临床特征及生存结果
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Choroidal and skin metastases from colorectal cancer.结直肠癌的脉络膜和皮肤转移
World J Gastroenterol. 2016 Nov 21;22(43):9650-9653. doi: 10.3748/wjg.v22.i43.9650.
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Difficult Diagnosis of Colon Adenocarcinoma Metastasis to Retina: A Case Report and Literature Review.结肠腺癌转移至视网膜的疑难诊断:一例报告及文献综述
Int J Hematol Oncol Stem Cell Res. 2016 Jul 1;10(3):186-90.
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Sci Rep. 2016 Jul 15;6:29765. doi: 10.1038/srep29765.
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Pattern of distant metastases in colorectal cancer: a SEER based study.结直肠癌远处转移模式:一项基于监测、流行病学和最终结果(SEER)数据库的研究
Oncotarget. 2015 Nov 17;6(36):38658-66. doi: 10.18632/oncotarget.6130.
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