School of Advanced Materials Science & Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Korea.
Chem Soc Rev. 2020 Mar 21;49(6):1812-1866. doi: 10.1039/c9cs00319c. Epub 2020 Feb 26.
The rapid growth of research in the areas of chemical and biochemical sensors, lab-on-a-chip, mobile technology, and wearable electronics offers an unprecedented opportunity in the development of mobile and wearable point-of-care testing (POCT) systems for self-testing. Successful implementation of such POCT technologies leads to minimal user intervention during operation to reduce user errors; user-friendly, easy-to-use and simple detection platforms; high diagnostic sensitivity and specificity; immediate clinical assessment; and low manufacturing and consumables costs. In this review, we discuss recent developments in the field of highly integrated mobile and wearable POCT systems. In particular, aspects of sample handling platforms, recognition elements and sensing methods, and new materials for signal transducers and powering devices for integration into mobile or wearable POCT systems will be highlighted. We also summarize current challenges and future prospects for providing personal healthcare with sample-in result-out mobile and wearable POCT.
化学和生化传感器、芯片实验室、移动技术以及可穿戴电子等领域的研究迅速发展，为自我检测的移动和可穿戴即时检测（POCT）系统的开发带来了前所未有的机遇。此类 POCT 技术的成功实施可减少操作过程中的用户干预，降低用户错误率；提供用户友好、易于使用和简单的检测平台；提高诊断灵敏度和特异性；实现即时临床评估；降低制造和耗材成本。在本综述中，我们讨论了高度集成的移动和可穿戴 POCT 系统领域的最新进展。特别是，将重点介绍样品处理平台、识别元件和传感方法以及用于信号转换器和供能设备的新材料等方面，这些都可集成到移动或可穿戴 POCT 系统中。我们还总结了在提供即时出结果的个人医疗保健方面，移动和可穿戴 POCT 目前面临的挑战和未来前景。
