School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 211816, China.
Analyst. 2021 Mar 7;146(5):1552-1558. doi: 10.1039/d0an02292f. Epub 2021 Jan 21.
Wearable sensors play a key role in point-of-care testing (POCT) for their flexible and integration capability for sensitive physiological and biochemical sensing. Here, we present a multifunction wearable silk patch with both electronic channels and microchannels by utilizing matrix-assisted sacrificial 3D printing methods. Owing to the unique properties of a composite silk film (polyvinyl alcohol (PVA) and silk fibroin (SF)), the wearable sensors possess excellent tensile properties, self-healing ability and biocompatibility. Multi-layer channel (microfluidics and microcircuit)-integrated silk wearable sensors were then fabricated for simultaneous sensitive sensing of human cancer markers (carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP)) and motion monitoring. These features of the silk wearable sensors indicate their potential value for sensitive sensing, which will enable them to find broader applications in many fields in POCT, artificial skin and organ-on-a-chip systems.
可穿戴传感器因其灵活的特性和对敏感生理及生化传感的集成能力，在即时检测（POCT）中发挥着关键作用。在这里，我们通过利用矩阵辅助牺牲 3D 打印方法，展示了一种具有电子通道和微通道的多功能可穿戴丝质贴片。由于复合丝膜（聚乙烯醇（PVA）和丝素蛋白（SF））的独特性质，可穿戴传感器具有优异的拉伸性能、自修复能力和生物相容性。然后，我们制造了多层通道（微流控和微电路）集成的丝质可穿戴传感器，用于同时敏感地检测人类癌症标志物（癌胚抗原（CEA）和甲胎蛋白（AFP））和运动监测。这些丝质可穿戴传感器的特点表明了它们在敏感传感方面的潜在价值，这将使它们能够在 POCT、人工皮肤和芯片上器官系统等许多领域找到更广泛的应用。
