Department of Ultrasound, Shanghai East Hospital, Tongji University, Shanghai, 200120, People's Republic of China.
Nanoscale Horiz. 2020 May 1;5(5):857-868. doi: 10.1039/c9nh00707e. Epub 2020 Feb 26.
Photothermal therapy (PTT) is an emerging technology as a noninvasive therapeutic modality for inducing photonic cancer hyperthermia. However, current photothermal conversion agents suffer from low therapeutic efficiency and single functionality. Engineering crystal defects on the surface or substrate of semiconductors can substantially enhance their optical absorption capability as well as improve their photothermal effects in theranostic nanomedicines. In this study, a specific defect engineering strategy was developed to endow two-dimensional (2D) BiOCl nanosheets with intriguing photothermal conversion performance by creating oxygen vacancies on the surface (O-BiOCl). Importantly, the photothermal performance and photoacoustic imaging capability of the 2D O-BiOCl nanosheets could be precisely controlled by modulating the amounts of oxygen vacancies. The strong Bi-based X-ray attenuation coefficient endowed these nanosheets with the contrast-enhanced computed tomography imaging capability. The high near-infrared-triggered photonic hyperthermia for tumor ablation was systematically demonstrated both in vitro at the cellular level and in vivo for tumor breast cancer mice xenograft models. Based on the demonstrated high biocompatibility of these 2D O-BiOCl nanosheets, this work not only formulates an intriguing 2D photothermal nanoagent for tumor ablation, but also provides an efficient strategy to control the photothermal performance of nanoagents by defect engineering.
光热疗法（PTT）是一种新兴的非侵入性治疗技术，可用于诱导光子癌症热疗。然而，目前的光热转换剂存在治疗效率低和功能单一的问题。在半导体的表面或衬底上进行工程晶体缺陷可以显著提高它们的光吸收能力，并改善它们在治疗纳米医学中的光热效应。在这项研究中，通过在表面上制造氧空位（O-BiOCl），开发了一种特定的缺陷工程策略，使二维（2D）BiOCl 纳米片具有引人注目的光热转换性能。重要的是，通过调节氧空位的数量，可以精确控制 2D O-BiOCl 纳米片的光热性能和光声成像能力。强的基于 Bi 的 X 射线衰减系数赋予这些纳米片具有增强的计算机断层扫描成像能力。在体外细胞水平和体内乳腺癌小鼠异种移植模型中，系统地证明了这些二维 O-BiOCl 纳米片具有强烈的近红外触发光子热疗以用于肿瘤消融。基于这些二维 O-BiOCl 纳米片表现出的高生物相容性，这项工作不仅为肿瘤消融制定了一种有趣的二维光热纳米剂，而且还提供了一种通过缺陷工程控制纳米剂光热性能的有效策略。
