Fang Qianlan, Xu Yu, Luo Lijia, Liu Chuang, Li Zihou, Lin Jie, Chen Tianxiang, Wu Aiguo
Cixi Institute of Biomedical Engineering, International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Science (CAS) Key Laboratory of Magnetic Materials and Devices and Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, CAS, Ningbo 315201, P.R. China.
Regen Biomater. 2022 Jun 6;9:rbac036. doi: 10.1093/rb/rbac036. eCollection 2022.
The recently emerging bismuth oxyhalide (BiOX) nanomaterials are promising indirect band gap photosensitizer for ultraviolet (UV) light-triggered phototherapy due to their unique layered nanosheet structure. However, the low absorption and poor photothermal conversion efficiency have always impeded their further applications in cancer clinical therapy. Herein, BiOCl rich in oxygen vacancies has been reported to have full-spectrum absorption properties, making it possible to achieve photothermal property under near-infrared laser. Under 808 nm irradiation, the photothermal conversion efficiency of black BiOCl nanosheets (BBNs) is up to 40%. BBNs@PEG can effectively clear primary subcutaneous tumors and prevent recurrence, achieving good synergistic treatment effect. These results not only broke the limitation of UV on the BiOCl material and provided a good template for other semiconductor materials, but also represent a promising approach to fabricate BBN@PEG a novel, potent and multifunctional theranostic platform for precise photothermal therapy and prognostic evaluation.
最近出现的卤氧化铋（BiOX）纳米材料因其独特的层状纳米片结构，有望成为用于紫外线（UV）光触发光疗的间接带隙光敏剂。然而，低吸收和差的光热转换效率一直阻碍着它们在癌症临床治疗中的进一步应用。在此，据报道富含氧空位的BiOCl具有全光谱吸收特性，使其在近红外激光下实现光热性能成为可能。在808nm照射下，黑色BiOCl纳米片（BBNs）的光热转换效率高达40%。BBNs@PEG能有效清除原发性皮下肿瘤并预防复发，实现良好的协同治疗效果。这些结果不仅打破了紫外线对BiOCl材料的限制，为其他半导体材料提供了良好的模板，还代表了一种有前景的方法来制造BBN@PEG这一新型、高效且多功能的诊疗平台，用于精确光热治疗和预后评估。
