Institute for Skeletal Aging & Orthopedic Surgery, Hallym University Hospital-College of Medicine, Chuncheon-si, Gangwon-do, Republic of Korea.
Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.
J Cell Biochem. 2020 Nov;121(11):4654-4666. doi: 10.1002/jcb.29683. Epub 2020 Feb 26.
Chronic lymphocytic leukemia (CLL), a severe problem all over the world and represents around 25% of all total leukemia cases, is generating the need for novel targets against CLL. Wnt signaling cascade regulates cell proliferation, differentiation, and cell death processes. Thus, any alteration of the Wnt signaling pathway protein cascade might develop into various types of cancers, either by upregulation or downregulation of the Wnt signaling pathway protein components. In addition, it is reported that activation of the Wnt signaling pathway is associated with the transcriptional activation of microRNAs (miRNAs) by binding to its promoter region, suggesting feedback regulation. Considering the protein regulatory functions of various miRNAs, they can be approached therapeutically as modulatory targets for protein components of the Wnt signaling pathway. In this article, we have discussed the potential role of miRNAs in the regulation of Wnt signaling pathway proteins related to the pathogenesis of CLL via crosstalk between miRNAs and Wnt signaling pathway proteins. This might provide a clear insight into the Wnt protein regulatory function of various miRNAs and provide a better understanding of developing advanced and promising therapeutic approaches against CLL.
慢性淋巴细胞白血病（CLL）是一种全球性的严重问题，占所有白血病病例的 25%左右，因此需要针对 CLL 的新靶点。Wnt 信号级联反应调节细胞增殖、分化和细胞死亡过程。因此，Wnt 信号通路蛋白级联的任何改变都可能通过上调或下调 Wnt 信号通路蛋白成分发展为各种类型的癌症。此外，据报道，Wnt 信号通路的激活与 microRNAs（miRNAs）的转录激活相关，通过与启动子区域结合来实现，表明存在反馈调节。考虑到各种 miRNA 的蛋白质调节功能，它们可以作为 Wnt 信号通路蛋白成分的调节靶点进行治疗。在本文中，我们通过 miRNA 和 Wnt 信号通路蛋白之间的相互作用，讨论了 miRNA 在调节与 CLL 发病机制相关的 Wnt 信号通路蛋白中的潜在作用。这可能为各种 miRNA 的 Wnt 蛋白调节功能提供清晰的认识，并为开发针对 CLL 的先进和有前途的治疗方法提供更好的理解。
