School of Biosciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Malaysia.
School of Biosciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Malaysia,
Lifestyle Genom. 2020;13(2):84-98. doi: 10.1159/000505662. Epub 2020 Feb 26.
Computing polygenic risk scores (PRS) to predict the degree of risk for obesity may contribute to weight management programs strategically.
To investigate the combined effect of FTO rs9930501, rs9930506, and rs9932754 and ADRB2 rs1042713 and rs1042714 using PRS on (1) the odds of obesity and (2) post-intervention differences in dietary, anthropometric, and cardiometabolic parameters in response to high-protein calorie-restricted, high-vitamin E, high-fiber (Hipcref) diet intervention in Malaysian adults.
Both a cross-sectional study (n = 178) and a randomized controlled trial (RCT) (n = 128) were conducted to test the aforementioned objectives. PRS was computed as the weighted sum of the risk alleles possessed by each individual participant. Participants were stratified into first (PRS 0-0.64), second (PRS 0.65-3.59), and third (PRS 3.60-8.18) tertiles.
The third tertile of PRS was associated with significantly higher odds of obesity: 2.29 (95% CI = 1.11-4.72, adjusted p = 0.025) compared to the first tertile. Indians (3.9 ± 0.3) had significantly higher PRS compared to Chinese (2.1 ± 0.4) (p = 0.010). In the RCT, a greater reduction in high-sensitivity C-reactive protein (hsCRP) levels was found in second and third tertiles after Hipcref diet intervention compared to the control diet (p interaction = 0.048).
Higher PRS was significantly associated with increased odds of obesity. Individuals with higher PRS had a significantly greater reduction in hsCRP levels after Hipcref diet compared to the control diet.
计算多基因风险评分 (PRS) 以预测肥胖的风险程度可能有助于战略性地管理体重。
研究 FTO rs9930501、rs9930506 和 rs9932754 以及 ADRB2 rs1042713 和 rs1042714 的联合效应，使用 PRS 对马来西亚成年人进行高蛋白热量限制、高维生素 E、高纤维 (Hipcref) 饮食干预后的（1）肥胖几率和（2）饮食、人体测量和心血管代谢参数的干预后差异进行研究。
进行了一项横断面研究（n = 178）和一项随机对照试验（RCT）（n = 128）来检验上述目标。PRS 被计算为每个个体参与者所拥有的风险等位基因的加权总和。参与者被分为第一（PRS 0-0.64）、第二（PRS 0.65-3.59）和第三（PRS 3.60-8.18）三分位。
PRS 的第三三分位与肥胖的几率显著增加相关：2.29（95% CI = 1.11-4.72，调整后的 p = 0.025）与第一三分位相比。印度人（3.9 ± 0.3）的 PRS 明显高于中国人（2.1 ± 0.4）（p = 0.010）。在 RCT 中，与对照饮食相比，Hipcref 饮食干预后第二和第三三分位的高敏 C 反应蛋白（hsCRP）水平显著降低（p 交互 = 0.048）。
较高的 PRS 与肥胖的几率显著相关。与对照饮食相比，Hipcref 饮食后 PRS 较高的个体 hsCRP 水平显著降低。
