马来西亚多民族成年人中 FTO rs9930506 对肥胖的影响以及基因变异与膳食蛋白质和维生素 E 对 C-反应蛋白水平的相互作用。

Effect of FTO rs9930506 on obesity and interaction of the gene variants with dietary protein and vitamin E on C-reactive protein levels in multi-ethnic Malaysian adults.

机构信息

School of Biosciences, Faculty of Science, University of Nottingham Malaysia Campus, Semenyih, Selangor Darul Ehsan, Malaysia.

School of Healthy Aging, Medical Aesthetics & Regenerative Medicine, UCSI University, Kuala Lumpur, Wilayah Persekutuan, Malaysia.

出版信息

J Hum Nutr Diet. 2018 Dec;31(6):758-772. doi: 10.1111/jhn.12593. Epub 2018 Aug 23.

DOI:10.1111/jhn.12593

PMID:30141234

Abstract

BACKGROUND

Individual variations of obesity-related traits can be a consequence of dietary influence on gene variants.

METHODS

This cross-sectional study aimed to evaluate (i) the effect of FTO rs9930506 on obesity and related parameters and (ii) the influence of diet on the above association in Malaysian adults. In total, 79 obese and 99 nonobese Malaysian adults were recruited.

RESULTS

In comparison with Chinese and Malays, Indians had significantly higher waist circumference (P ≤ 0.001 and P = 0.016), waist-hip ratio (P = 0.001 and P < 0.001), body fat percentage (P = 0.001 and P = 0.042), fasting insulin (P = 0.001 and P = 0.001), homeostatic model assessment-insulin resistance (P = 0.001 and P = 0.001) and lower high-density lipoprotein-cholesterol levels (P < 0.001 and P < 0.001), respectively. Indians consumed significantly lower dietary cholesterol (P = 0.002), percentage energy from protein (P < 0.001) and higher fibre (P = 0.006) compared to the other two groups. Malaysian Indians expressed the highest risk allele frequency (G) of FTO rs9930506 compared to the Malays and the Chinese (P < 0.001). No significant association was found between FTO rs9930506 and obesity (dominant model). Risk allele carriers (G) consumed significantly lower vitamin E (P = 0.020) and had a higher fibre intake (P = 0.034) compared to the noncarriers (A). Gene-diet interaction analysis revealed that risk allele carriers (G) had lower high sensitivity C-reactive protein (hsCRP) levels with higher energy from protein (≥14% day ; P = 0.049) and higher vitamin E (≥5.4 mg day ; P = 0.038).

CONCLUSIONS

The presence of the risk allele (G) of FTO rs9930506 was not associated with an increased risk of obesity. Malaysian Indians had a significantly higher frequency of the risk allele (G). Indian participants expressed higher atherogenic phenotypes compared to Chinese and Malays. FTO rs9930506 may interact with dietary protein and vitamin E and modulate hsCRP levels.

摘要

背景

肥胖相关特征的个体差异可能是饮食对基因变异影响的结果。

方法

本横断面研究旨在评估（i）FTO rs9930506 对肥胖和相关参数的影响，以及（ii）饮食对马来西亚成年人上述关联的影响。共招募了 79 名肥胖者和 99 名非肥胖者。

结果

与中国人和马来人相比，印度人腰围（P ≤ 0.001 和 P = 0.016）、腰臀比（P = 0.001 和 P < 0.001）、体脂百分比（P = 0.001 和 P = 0.042）、空腹胰岛素（P = 0.001 和 P = 0.001）、稳态模型评估-胰岛素抵抗（P = 0.001 和 P = 0.001）更高，而高密度脂蛋白胆固醇水平（P < 0.001 和 P < 0.001）更低。与其他两组相比，印度人摄入的膳食胆固醇（P = 0.002）、蛋白质供能百分比（P < 0.001）更低，而纤维（P = 0.006）更高。与马来人和中国人相比，马来西亚印度人表达的 FTO rs9930506 风险等位基因频率（G）最高（P < 0.001）。FTO rs9930506 与肥胖（显性模型）之间未发现显著关联。风险等位基因携带者（G）摄入的维生素 E（P = 0.020）和纤维（P = 0.034）明显低于非携带者（A）。基因-饮食相互作用分析显示，风险等位基因携带者（G）在摄入更高蛋白质（≥14% 日；P = 0.049）和更高维生素 E（≥5.4 mg 日；P = 0.038）时，hsCRP 水平较低。