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Modulating the oxygen tension in tumours by hypothermia and hyperbaric oxygen.通过低温和高压氧调节肿瘤中的氧张力。
J R Soc Med. 1988 Nov;81(11):633-6. doi: 10.1177/014107688808101106.
2
Effect of hypothermia on radiosensitization.低温对放射增敏作用的影响。
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Effect of heat and ionizing radiation on normal and neoplastic tissue of the C3H mouse.热和电离辐射对C3H小鼠正常组织和肿瘤组织的影响。
Radiat Res. 1975 Aug;63(2):363-77.
4
The response of spontaneous mammary tumours in C3H mice to methotrexate and radiation under hyperbaric oxygenation.
Br J Radiol. 1972 Oct;45(538):802.
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Combined therapy of the spontaneous mouse mammary tumour: methotrexate and hyperbaric oxygen irradiation.自发性小鼠乳腺肿瘤的联合治疗：甲氨蝶呤与高压氧照射
Eur J Cancer (1965). 1977 Sep;13(9):977-84. doi: 10.1016/0014-2964(77)90176-1.
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Chronic anaemia, hyperbaric oxygen and tumour radiosensitivity.
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The mechanisms by which hyperbaric oxygen and carbogen improve tumour oxygenation.高压氧和混合气改善肿瘤氧合的机制。
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Concurrent Longitudinal EPR Monitoring of Tissue Oxygenation, Acidosis, and Reducing Capacity in Mouse Xenograft Tumor Models.小鼠异种移植肿瘤模型中组织氧合、酸中毒和还原能力的同步纵向电子顺磁共振监测
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Fever-range hyperthermia vs. hypothermia effect on cancer cell viability, proliferation and HSP90 expression.发热范围的高温与低温对癌细胞活力、增殖及热休克蛋白90（HSP90）表达的影响
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Localized hypothermia: impact on oxygenation, microregional perfusion, metabolic and bioenergetic status of subcutaneous rat tumours.局部低温：对大鼠皮下肿瘤的氧合、微区域灌注、代谢及生物能量状态的影响
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本文引用的文献

1
Regional blood flow by fractional distribution of indicators.通过指标的分数分布来评估局部血流量。
Am J Physiol. 1958 Apr;193(1):161-8. doi: 10.1152/ajplegacy.1958.193.1.161.
2
The histological structure of some human lung cancers and the possible implications for radiotherapy.一些人类肺癌的组织学结构及其对放射治疗的可能影响。
Br J Cancer. 1955 Dec;9(4):539-49. doi: 10.1038/bjc.1955.55.
3
Carcinoma of the cervix--anaemia, radiotherapy and hyperbaric oxygen.
Br J Radiol. 1983 Apr;56(664):251-5. doi: 10.1259/0007-1285-56-664-251.
4
The use of ketamine plus diazepam anaesthesia to increase the radiosensitivity of a C3H mouse mammary adenocarcinoma in hyperbaric oxygen.
Br J Radiol. 1984 Jan;57(673):75-80. doi: 10.1259/0007-1285-57-673-75.
5
Abnormal response of tumor vasculature to vasoactive drugs.肿瘤血管对血管活性药物的异常反应。
J Natl Cancer Inst. 1984 Jan;72(1):145-50. doi: 10.1093/jnci/72.1.145.
6
A feasibility study of a new approach to clinical radiosensitisation: hypothermia and hyperbaric oxygen in combination with pharmacological vasodilatation.一种临床放射增敏新方法的可行性研究：低温、高压氧联合药物性血管舒张
Br J Radiol. 1986 Nov;59(707):1093-8. doi: 10.1259/0007-1285-59-707-1093.
7
Effect of hypothermia on radiosensitization.低温对放射增敏作用的影响。
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Aug;50(2):241-51. doi: 10.1080/09553008614550631.

通过低温和高压氧调节肿瘤中的氧张力。

Modulating the oxygen tension in tumours by hypothermia and hyperbaric oxygen.

作者信息

Nias A H, Perry P M, Photiou A R

机构信息

Richard Dimbleby Department of Cancer Research, United Medical School, St Thomas's Hospital, London.

出版信息

J R Soc Med. 1988 Nov;81(11):633-6. doi: 10.1177/014107688808101106.

DOI:10.1177/014107688808101106
PMID:3210193
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1291839/
Abstract

Hypothermia is associated with reduced metabolism of tissues and especially reduced oxygen consumption by tumours. If the blood supply to a hypothermic tumour can be maintained then the hypoxic fraction of cells should be reduced and the radiation response increased. This hypothesis has been tested with radiation under hyperbaric oxygen and increased tumour response has been demonstrated.

摘要

体温过低与组织代谢降低有关，尤其是肿瘤的氧消耗减少。如果能维持对低温肿瘤的血液供应，那么细胞的缺氧部分应会减少，放射反应会增强。这一假说已在高压氧条件下进行放射测试，并已证明肿瘤反应增强。