Sealy R, Harrison G G, Morrell D, Korrubel J, Gregory A, Barry L, Blekkenhorst G, Hering E R, Fataar A B, Boniaszczuk J
Br J Radiol. 1986 Nov;59(707):1093-8. doi: 10.1259/0007-1285-59-707-1093.
It is proposed that hyperbaric oxygen fails in the clinical situation due to a high proportion (greater than 33%) of hypoxic cells in human tumours. The means of overcoming this problem are reviewed. Additional to hyperbaric oxygenation, moderate hypothermia (30 degrees C) to allow redistribution of oxygen in the tumour is proposed. A system of externally controlled intravenous anaesthesia has been developed for the single-subject hyperbaric cylinder. Pharmacological vasodilatation is induced in the anaesthetised patient who is then fluid loaded and cooled. Initial single-sensitising treatments are advocated. Twenty-nine patients with advanced mouth cancer have completed a course of this treatment, of whom five of nine were free of disease after 2 years and 10 of 21 at 1 year, with three intercurrent deaths. Fifteen have experienced local failure. This approach would appear to be practical, safe and promising.
有人提出，高压氧在临床情况下无效是因为人类肿瘤中存在高比例（超过33%）的缺氧细胞。本文综述了克服这一问题的方法。除了高压氧合，还提出采用适度低温（30摄氏度）以使肿瘤内的氧气重新分布。已为单人高压氧舱开发了一种外部控制的静脉麻醉系统。对麻醉患者进行诱导性药理血管舒张，然后给予液体负荷并进行降温。提倡进行初始单敏化治疗。29例晚期口腔癌患者完成了这一疗程的治疗，其中9例中有5例在2年后无疾病，21例中有10例在1年后无疾病，有3例并发死亡。15例出现局部失败。这种方法似乎切实可行、安全且有前景。
