Dargahi Narges, Matsoukas John, Apostolopoulos Vasso
Institute for Health and Sport, Victoria University, Melbourne VIC 3030, Australia.
NewDrug, Patras Science Park, Patras 26500, Greece.
Brain Sci. 2020 Feb 23;10(2):126. doi: 10.3390/brainsci10020126.
Probiotic bacteria have beneficial effects to the development and maintenance of a healthy microflora that subsequently has health benefits to humans. Some of the health benefits attributed to probiotics have been noted to be via their immune modulatory properties suppressing inflammatory conditions. Hence, probiotics have become prominent in recent years of investigation with regard to their health benefits. As such, in the current study, we determined the effects of Streptococcus thermophilus to agonist MBP peptide immunized mouse spleen cells. It was noted that Streptococcus thermophilus induced a significant increase in the expression of anti-inflammatory IL-4, IL-5, IL-10 cytokines, and decreased the secretion of pro-inflammatory IL-1β and IFN-γ Regular consumption of Streptococcus thermophilus may therefore be beneficial in the management and treatment of autoimmune diseases such as multiple sclerosis.
益生菌对健康微生物群的发育和维持具有有益作用，而健康的微生物群随后会对人类健康产生益处。一些归因于益生菌的健康益处已被指出是通过其免疫调节特性来抑制炎症状态。因此，近年来关于益生菌的健康益处的研究备受关注。在此，在当前的研究中，我们确定了嗜热链球菌对用激动剂髓鞘碱性蛋白（MBP）肽免疫的小鼠脾细胞的影响。值得注意的是，嗜热链球菌诱导抗炎细胞因子白细胞介素-4（IL-4）、白细胞介素-5（IL-5）、白细胞介素-10（IL-10）的表达显著增加，并减少促炎细胞因子白细胞介素-1β（IL-1β）和干扰素-γ（IFN-γ）的分泌。因此，经常食用嗜热链球菌可能对自身免疫性疾病如多发性硬化症的管理和治疗有益。
