Kongjam Panida, Jeyaseelan Lakshmanan, Chaijaroenkul Wanna, Na-Bangchang Kesara
Chulabhorn International College of Medicine, Thammasat University, Paholyothin Road, Klongluang, Pathumthani Thailand.
Department of Biostatistics, Christian Medical College, Vellore-632 002, India.
Asian Pac J Cancer Prev. 2020 Feb 1;21(2):275-280. doi: 10.31557/APJCP.2020.21.2.275.
The aim of the study was to perform a systematic review of research articles related to cholangiocarcinoma (CCA), the bile duct cancer in Southeast Asian (SEA) countries published during 2010-2015 including analysis of inappropriate use/misuse of statistics.
Research articles were retrieved from the PubMed database using different 'keywords' for seven research disciplines/categories in biomedical sciences (medicine/physiology, epidemiology, immunology, pharmacology and toxicology, diagnosis/diagnostics, drug resistance, and biochemistry).
A total of 353 articles were finally included in the analysis based on the pre-defined eligibility criteria. Most were articles of which the studies were conducted in Thailand (335 articles, 94.90%). Disease diagnosis/diagnostics (n=266, 75.35%), biochemistry (n =223, 63.17%), and pharmacology and toxicology (n =218, 61.76%) were the three main research disciplines/categories for CAA conducted in SEA countries during 2010-2015. Thailand was the country which most published CCA-related research articles in all disciplines/categories. Drug resistance was the research category that most applied both descriptive and inferential statistics (100%). The student's t-test was the most applied test (35.13%). Inappropriate use/misuse of statistics in all types was highest in diagnosis/diagnostics (73.59%) and pharmacology and toxicology (73.06%) research disciplines/categories and was lowest in medicine/pathophysiology (0.26%). Inappropriate use/misuse in almost all types (seven types) was found in the diagnosis/diagnostics category.
Results of the systematic analysis of CCA-related research articles published from the ten SEA countries during 2010-2015 reveal high rates of inappropriate use/misuse of statistics. The readers should be aware of the reliability of the articles and the possibility of wrong interpretation and conclusion of these articles.
本研究旨在对2010年至2015年间发表的与东南亚国家胆管癌（CCA）相关的研究文章进行系统综述，包括分析统计方法的不当使用/误用情况。
使用生物医学科学七个研究学科/类别的不同“关键词”，从PubMed数据库中检索研究文章（医学/生理学、流行病学、免疫学、药理学与毒理学、诊断/诊断学、耐药性和生物化学）。
根据预先定义的纳入标准，最终共有353篇文章纳入分析。大多数文章的研究是在泰国进行的（335篇文章，94.90%）。疾病诊断/诊断学（n = 266，75.35%）、生物化学（n = 223，63.17%）以及药理学与毒理学（n = 218，61.76%）是2010年至2015年间东南亚国家开展的CCA研究的三个主要研究学科/类别。泰国是在所有学科/类别中发表CCA相关研究文章最多的国家。耐药性是最常应用描述性和推断性统计的研究类别（100%）。学生t检验是应用最广泛的检验方法（35.13%）。在诊断/诊断学（73.59%）和药理学与毒理学（73.06%）研究学科/类别中，各类统计方法的不当使用/误用率最高，而在医学/病理生理学中最低（0.26%）。在诊断/诊断学类别中，几乎所有类型（七种类型）的统计方法都存在不当使用/误用情况。
对2010年至2015年间十个东南亚国家发表的CCA相关研究文章进行系统分析的结果显示，统计方法的不当使用/误用率很高。读者应意识到这些文章的可靠性以及对这些文章进行错误解读和得出错误结论的可能性。
