Kurashige S, Akuzawa Y, Fujii N, Kishi S, Takeshita M, Miyamoto Y
College of Medical Care and Technology, Gunma University, Japan.
Jpn J Exp Med. 1988 Aug;58(4):197-202.
We studied the effect of vitamin B complex (vitamin B1, B6 and B12 complex) on the immune responsiveness in gastric cancer patients who underwent surgery. The depression of blastogenic responses to both PHA and PWM was observed 2 weeks after surgery in half of the patients treated with Vitamedin but the degree was significantly less than that in the control patients without vitamin B treatment whose lymphocyte responses were depressed. Moreover, the blastogenic responses were induced by vitamin B administration 2 or 4 weeks after surgery in 5 of the 8 stage III-IV patients whose lymphocytes had not responded prior to surgery. Four weeks after surgery, the patients without vitamin B treatment showed only a tendency of recovery of their lymphocyte responses, whereas the recovery of blastogenic responses in the patients treated with vitamin B was significant. Essentially similar results were obtained with skin reactions to PHA and PPD. These results suggest that the administration of vitamin B1, B6 and B12 complex is useful for the protection against and the recovery of immune dysfunction produced by surgery in cancer patients.
我们研究了复合维生素B（维生素B1、B6和B12复合物）对接受手术的胃癌患者免疫反应性的影响。在接受维他命丁治疗的患者中，术后2周有一半患者对PHA和PWM的增殖反应出现抑制，但抑制程度明显低于未接受维生素B治疗的对照患者，后者的淋巴细胞反应受到抑制。此外，在8例III-IV期患者中，有5例术前淋巴细胞无反应，术后2或4周给予维生素B后诱导出了增殖反应。术后4周，未接受维生素B治疗的患者淋巴细胞反应仅呈现恢复趋势，而接受维生素B治疗的患者增殖反应的恢复则很显著。对PHA和PPD的皮肤反应也得到了基本相似的结果。这些结果表明，给予复合维生素B1、B6和B12有助于预防和恢复癌症患者手术所致的免疫功能障碍。
