细菌易位和自噬对重症急性胰腺炎所致急性肺损伤的影响。
Effects of Bacterial Translocation and Autophagy on Acute Lung Injury Induced by Severe Acute Pancreatitis.
作者信息
Wang Hanlin, Li Chang, Jiang Yingjian, Li Hongbo, Zhang Dianliang
机构信息
Center of Colon and Rectum, Qingdao Municipal Hospital, Qingdao University, No. 1 Jiaozhou Road, Qingdao, 266011 Shandong Province, China.
出版信息
Gastroenterol Res Pract. 2020 Feb 13;2020:8953453. doi: 10.1155/2020/8953453. eCollection 2020.
AIM
To reveal the role of bacterial translocation (BT) and autophagy in severe acute pancreatitis-induced acute lung injury (SAP-ALI).
METHODS
Rats were separated into a control (sham-operation) group ( = 10) and a SAP group ( = 10) and a SAP group (.
RESULTS
Levels of TNF-, IL-6, lipase, and amylase in the SAP group were significantly higher than those in the control group ( < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group ( < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group ( < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group ( < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group ( < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group ( < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (.
CONCLUSIONS
BT can aggravate SAP-ALI with the increasing oxidative stress level, which may be related to the decrease of autophagy level.
目的
揭示细菌移位（BT）和自噬在重症急性胰腺炎诱导的急性肺损伤（SAP-ALI）中的作用。
方法
将大鼠分为对照组（假手术组）（n = 10）和SAP组（n = 10）以及一个SAP组（此处原文表述有误）。
结果
SAP组中肿瘤坏死因子-α、白细胞介素-6、脂肪酶和淀粉酶水平显著高于对照组（P < 0.01）。SAP-BT(+)组肺组织病理评分和肺湿/干重比显著高于SAP-BT(-)组（P < 0.01）。SAP-BT(+)组肺组织病理评分和肺湿/干重比显著高于SAP-BT(-)组（P < 0.01）。SAP-BT(+)组肺组织病理评分和肺湿/干重比显著高于SAP-BT(-)组（P < 0.01）。SAP-BT(+)组肺组织病理评分和肺湿/干重比显著高于SAP-BT(-)组（P < 0.01）。SAP-BT(+)组肺组织病理评分和肺湿/干重比显著高于SAP-BT(-)组（P < 0.01）。SAP-BT(+)组肺组织病理评分和肺湿/干重比显著高于SAP-BT(-)组（此处原文重复且有误）。
结论
BT可随着氧化应激水平升高加重SAP-ALI，这可能与自噬水平降低有关。
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