Kathe Kashmira, Kathpalia Harsha
Department of Pharmaceutics, Vivekanand Education Society's College of Pharmacy, Chembur, Mumbai, Maharashtra 400074, India.
Asian J Pharm Sci. 2017 Nov;12(6):487-497. doi: 10.1016/j.ajps.2017.07.004. Epub 2017 Jul 5.
Skin is considered as an important route of administration of drugs for both local and systemic effects. The effectiveness of topical therapy depends on the physicochemical properties of the drug and adherence of the patient to the treatment regimen as well as the system's ability to adhere to skin during the therapy so as to promote drug penetration through the skin barrier. Conventional formulations for topical and dermatological administration of drugs have certain limitations like poor adherence to skin, poor permeability and compromised patient compliance. For the treatment of diseases of body tissues and wounds, the drug has to be maintained at the site of treatment for an effective period of time. Topical film forming systems are such developing drug delivery systems meant for topical application to the skin, which adhere to the body, forming a thin transparent film and provide delivery of the active ingredients to the body tissue. These are intended for skin application as emollient or protective and for local action or transdermal penetration of medicament for systemic action. The transparency is an appreciable feature of this polymeric system which greatly influences the patient acceptance. In the current discussion, the film forming systems are described as a promising choice for topical and transdermal drug delivery. Further the various types of film forming systems (sprays/solutions, gels and emulsions) along with their evaluation parameters have also been reviewed.
皮肤被认为是药物局部和全身作用的重要给药途径。局部治疗的有效性取决于药物的物理化学性质、患者对治疗方案的依从性以及治疗期间给药系统与皮肤的黏附能力，以便促进药物透过皮肤屏障。传统的局部和皮肤科给药制剂存在一定局限性，如对皮肤的黏附性差、渗透性差以及患者依从性不佳。对于身体组织疾病和伤口的治疗，药物必须在治疗部位维持有效时长。局部成膜系统是一类正在发展的给药系统，旨在局部应用于皮肤，黏附于身体，形成一层薄的透明膜，并将活性成分递送至身体组织。这些制剂旨在作为润肤剂或保护剂用于皮肤，以及用于药物的局部作用或经皮渗透以产生全身作用。透明度是这种聚合物系统的一个显著特征，极大地影响患者的接受度。在当前的讨论中，成膜系统被描述为局部和经皮给药的一个有前景的选择。此外，还综述了各种类型的成膜系统（喷雾剂/溶液、凝胶和乳液）及其评价参数。
