Banov Daniel, Song Guiyun, Foraida Zahraa, Tkachova Oksana, Zdoryk Oleksandr, Carvalho Maria
Professional Compounding Centers of America (PCCA), Houston, TX 77099, USA.
Department of Pharmaceutical Management and Marketing, National University of Pharmacy, 61002 Kharkiv, Ukraine.
Gels. 2024 Jul 5;10(7):447. doi: 10.3390/gels10070447.
The study aimed to perform a comprehensive in vitro and in vivo evaluation of a newly developed, patent-pending, powder-to-hydrogel, film-forming polymer complex base, which possesses tissue-protective and microbiome-supportive properties, and to compare its characteristics with poloxamer 407. The study used a combination of in vitro assays, including tissue viability and cell migration, and in vivo wound healing evaluations in male diabetic mice. Microbiome dynamics at wound sites were also analyzed. The in vitro assays demonstrated that the polymer complex base was non-cytotoxic and that it enhanced cell migration over poloxamer 407. In vivo, the polymer complex base demonstrated superior wound healing capabilities, particularly in combination with misoprostol and phenytoin, as evidenced by the reduced wound area and inflammation scores. Microbiome analysis revealed favorable shifts in bacterial populations associated with the polymer complex base-treated wounds. The polymer complex base demonstrates clinical significance in wound care, potentially offering improved healing, safety and microbiome support. Its transformative properties and efficacy in drug delivery make it a promising candidate for advanced wound care applications, particularly in chronic wound management.
该研究旨在对一种新开发的、正在申请专利的粉末-水凝胶成膜聚合物复合物基质进行全面的体外和体内评估，该基质具有组织保护和微生物群支持特性，并将其特性与泊洛沙姆407进行比较。该研究采用了多种体外试验方法，包括组织活力和细胞迁移试验，以及对雄性糖尿病小鼠的体内伤口愈合评估。还分析了伤口部位的微生物群动态。体外试验表明，该聚合物复合物基质无细胞毒性，且与泊洛沙姆407相比能促进细胞迁移。在体内，该聚合物复合物基质表现出卓越的伤口愈合能力，尤其是与米索前列醇和苯妥英联合使用时，伤口面积减小和炎症评分降低证明了这一点。微生物群分析显示，与该聚合物复合物基质处理的伤口相关的细菌种群发生了有利变化。该聚合物复合物基质在伤口护理方面具有临床意义，可能提供更好的愈合效果、安全性和微生物群支持。其在药物递送方面的变革性特性和功效使其成为高级伤口护理应用的有前途的候选者，特别是在慢性伤口管理方面。
