Orfanu Alina, Aramă Victoria, Popescu Cristina, Tilişcan Cătălin, Streinu-Cercel Adrian, Aramă Ştefan Sorin
National Institute for Infectious Diseases "Prof. Dr. Matei Bals", Bucharest Romania.
University of Medicine and Pharmacy "Carol Davila", Bucharest Romania.
J Crit Care Med (Targu Mures). 2020 Jan 31;6(1):25-31. doi: 10.2478/jccm-2020-0004. eCollection 2020 Jan.
To evaluate the kinetics of inflammatory biomarkers in septic patients in order to identify the most reliable predictor of unfavorable outcome.
A prospective analysis of septic patients was performed. Median levels of neutrophil/lymphocyte count ratio, fibrinogen, C-reactive protein and procalcitonin were dynamically assessed and comparatively analyzed.
Seventy-seven patients were included. Descendent kinetic patterns were registered for all biomarkers, except C-reactive protein. At 24 hours, neutrophil/lymphocyte count ratio significantly decreased in 42.85% of cases, procalcitonin in 37.33%, C-reactive protein in 16.12% and fibrinogen in 1.58% of cases. At 72 hours, procalcitonin decreased to one-half in 70% of cases and neutrophil/lymphocyte count ratio in 67.53% of cases.
Neutrophil/lymphocyte count ratio and procalcitonin significantly decreased in the first 72 hours, while C-reactive protein increased in the first 24 hours. The proportions of patients with major decrease of baseline values were higher for neutrophil/lymphocyte count ratio and procalcitonin.
评估脓毒症患者炎症生物标志物的动力学变化，以确定不良预后最可靠的预测指标。
对脓毒症患者进行前瞻性分析。动态评估并比较中性粒细胞/淋巴细胞计数比值、纤维蛋白原、C反应蛋白和降钙素原的中位数水平。
纳入77例患者。除C反应蛋白外，所有生物标志物均呈现下降的动力学模式。在24小时时，42.85%的病例中性粒细胞/淋巴细胞计数比值显著下降，37.33%的病例降钙素原下降，16.12%的病例C反应蛋白下降，1.58%的病例纤维蛋白原下降。在72小时时，70%的病例降钙素原降至一半，67.53%的病例中性粒细胞/淋巴细胞计数比值下降。
中性粒细胞/淋巴细胞计数比值和降钙素原在最初72小时显著下降，而C反应蛋白在最初24小时升高。中性粒细胞/淋巴细胞计数比值和降钙素原基线值大幅下降的患者比例更高。
