Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología I. Ch. 14080, Ciudad de México, México.
Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología I. Ch. 14080, Ciudad de México, México.
Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165744. doi: 10.1016/j.bbadis.2020.165744. Epub 2020 Feb 24.
Cardiolipin (CL) is an acidic phospholipid almost exclusively found in the inner mitochondrial membrane, that not only stabilizes the structure and function of individual components of the mitochondrial electron transport chain, but regulates relevant mitochondrial processes, like mitochondrial dynamics and cristae structure maintenance among others. Alterations in CL due to peroxidation, correlates with loss of such mitochondrial activities and disease progression. In this review it is recapitulated the current state of knowledge of the role of cardiolipin remodeling associated with mitochondrial dysfunction in metabolic and cardiovascular diseases.
心磷脂（CL）是一种酸性磷脂，几乎只存在于线粒体内膜中，它不仅稳定了线粒体电子传递链各个组成部分的结构和功能，而且调节了相关的线粒体过程，如线粒体动力学和嵴结构的维持等。由于过氧化引起的 CL 改变，与这些线粒体活性的丧失和疾病的进展相关。在这篇综述中，我们概括了与线粒体功能障碍相关的心磷脂重塑在代谢和心血管疾病中的作用的最新知识状态。
