Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" from Timisoara, 300645, Calea Aradului 119, Timisoara, Timis, Romania.
Sci Rep. 2020 Feb 27;10(1):3569. doi: 10.1038/s41598-020-60657-4.
The nanostructure pharmaceutical formulations (NPF) which contains testosterone undecanoate (TU) been used in life science as parent compound delivery systems for therapeutic, but and been used to enhance the performance in sport, so it is a significant substance for public health and nutritional supplements. In most Pharmacopoeias testosterone is described as an ester of some lower acids (often propionate). The aim of this study is to determine purity of the parent compound by chromatography and absorption spectrum in the frame of middle infrared. Chemical structure of undecanoate was prepared and used in order to achieve a better absorption. This is explained by increased lipophilicity of undecanoate. Due to its lipophilic character, TU is soluble in non-polar solvents but shows a satisfactory solubility in absolute ethanol. Based on the molecular structure, a moderate absorption in the frame of UV with a maximum absorption at a not too high wave-length can be predicted. Maximum absorption occurs in a spectral region in which usual ingredients do not present significant interference.
纳米结构药物制剂（NPF）中含有十一酸睾酮（TU），被广泛应用于生命科学领域，作为母体化合物的药物输送系统，用于治疗各种疾病。此外，它也被用于提高运动员的运动表现，因此它是公共健康和营养补充品领域的重要物质。在大多数药典中，睾酮被描述为某些低级酸（通常是丙酸）的酯。本研究的目的是通过中红外吸收光谱法和色谱法来确定母体化合物的纯度。为了获得更好的吸收效果，我们制备了十一酸酯的化学结构并加以应用。这是由于十一酸酯的亲脂性增加所致。由于其亲脂性，TU 可溶于非极性溶剂，但在无水乙醇中溶解度良好。基于分子结构，可以预测 TU 在紫外光区有适度的吸收，最大吸收波长不会太高。最大吸收发生在通常成分不会产生显著干扰的光谱区域。
