Manitoba Centre for Proteomics and Systems Biology, Department of Internal Medicine and Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.
La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Nat Rev Drug Discov. 2020 May;19(5):311-332. doi: 10.1038/s41573-019-0058-8. Epub 2020 Feb 27.
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally occurring peptides that can combat infections through their direct microbicidal properties and/or by influencing the host's immune responses. The unique ability of CHDP to control infections as well as resolve harmful inflammation has generated interest in harnessing the properties of these peptides to develop new therapies for infectious diseases, chronic inflammatory disorders and wound healing. Various strategies have been used to design synthetic optimized peptides, with negligible toxicity. Here, we focus on the progress made in understanding the scope of functions of CHDP and the emerging potential clinical applications of CHDP-based therapies.
阳离子防御肽（CHDP），也被称为抗菌肽，是天然存在的肽，可通过其直接的杀菌特性和/或影响宿主的免疫反应来对抗感染。CHDP 控制感染和消除有害炎症的独特能力引起了人们的兴趣，希望利用这些肽的特性来开发治疗感染性疾病、慢性炎症性疾病和伤口愈合的新疗法。已经使用了各种策略来设计具有可忽略毒性的合成优化肽。在这里，我们重点介绍了在理解 CHDP 的功能范围和基于 CHDP 的治疗方法的新兴潜在临床应用方面取得的进展。
