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应用三相骨植入材料增强骨质疏松性椎体的局部骨强度：一项生物力学研究。

Local osteo-enhancement of osteoporotic vertebra with a triphasic bone implant material increases strength-a biomechanical study.

机构信息

Department of Orthopaedics and Traumatology, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.

Department of Trauma Surgery, Medical University of Innsbruck, Innsbruck, Austria.

出版信息

Arch Orthop Trauma Surg. 2020 Oct;140(10):1395-1401. doi: 10.1007/s00402-020-03382-x. Epub 2020 Feb 27.

DOI:10.1007/s00402-020-03382-x
PMID:32108254
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7505880/
Abstract

PURPOSE

The aim of this study was to assess the biomechanical properties of intact vertebra augmented using a local osteo-enhancement procedure to inject a triphasic calcium sulfate/calcium phosphate implant material.

METHODS

Twenty-one fresh frozen human cadaver vertebra (Th11-L2) were randomized into three groups: treatment, sham, and control (n = 7 each). Treatment included vertebral body access, saline lavage to displace soft tissue and marrow elements, and injection of the implant material to fill approximately 20% of the vertebral body by volume. The sham group included all treatment steps, but without injection of the implant material. The control group consisted of untreated intact osteoporotic vertebra. Load at failure and displacement at failure for each of the three groups were measured in axial compression loading.

RESULTS

The mean failure load of treated vertebra (4118 N) was significantly higher than either control (2841 N) or sham (2186 N) vertebra (p < 0.05 for: treatment vs. control, treatment vs. sham). Treated vertebra (1.11 mm) showed a significantly higher mean displacement at failure than sham vertebra (0.80 mm) (p < 0.05 for: treatment vs. sham). In the control group, the mean displacement at failure was 0.99 mm.

CONCLUSIONS

This biomechanical study shows that a local osteo-enhancement procedure using a triphasic implant material significantly increases the load at failure and displacement at failure in cadaveric osteoporotic vertebra.

摘要

目的

本研究旨在评估使用局部骨增强术注射三相硫酸钙/磷酸钙植入物材料增强完整椎体的生物力学性能。

方法

21 个新鲜冷冻人尸体椎体（Th11-L2）随机分为三组：治疗组、假手术组和对照组（每组 7 个）。治疗组包括椎体进入、生理盐水冲洗以置换软组织和骨髓成分，以及注射植入物材料以填充约 20%的椎体体积。假手术组包括所有治疗步骤，但不注射植入物材料。对照组由未经处理的完整骨质疏松椎体组成。在轴向压缩加载下测量三组的失效载荷和失效位移。

结果

治疗组的平均失效载荷（4118 N）明显高于对照组（2841 N）或假手术组（2186 N）（治疗与对照、治疗与假手术相比，p<0.05）。治疗组的平均失效位移（1.11 毫米）明显高于假手术组（0.80 毫米）（治疗与假手术相比，p<0.05）。在对照组中，平均失效位移为 0.99 毫米。

结论

这项生物力学研究表明，使用三相植入物材料的局部骨增强术可显著增加骨质疏松椎体的失效载荷和失效位移。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/7505880/23a761b7053f/402_2020_3382_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/7505880/2daa881706e0/402_2020_3382_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/7505880/ca0e36e9dccf/402_2020_3382_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/7505880/c9d2d62d5333/402_2020_3382_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/7505880/23a761b7053f/402_2020_3382_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/7505880/2daa881706e0/402_2020_3382_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/7505880/ca0e36e9dccf/402_2020_3382_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/7505880/c9d2d62d5333/402_2020_3382_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de41/7505880/23a761b7053f/402_2020_3382_Fig4_HTML.jpg

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