Department of Radiation Oncology, University of Maryland Medical Center, 22 South Greene Street, Baltimore, MD, 21201, USA.
Department of Radiation Oncology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD, 21201, USA.
Curr Oncol Rep. 2020 Feb 27;22(3):30. doi: 10.1007/s11912-020-0889-9.
Proton beam therapy (PBT) allows for improved sparing of surrounding normal tissues compared with X-ray-based radiation therapy. This is especially important in the setting of liver malignancies, where an increase in integral dose leads to a higher risk of radiation-induced liver disease (RILD) as well as close proximity to vital gastrointestinal (GI) organs.
We have data from multiple centers demonstrating that PBT can safely deliver high, ablative doses of radiation therapy conferring excellent local control with good tolerance of treatment. PBT is an effective treatment with longstanding evidence of efficacy that is increasing in availability.
与基于 X 射线的放射治疗相比，质子束治疗（PBT）可更好地保护周围正常组织。在肝脏恶性肿瘤的治疗中，这一点尤为重要，因为积分剂量的增加会导致放射性肝损伤（RILD）的风险增加，并且与重要的胃肠道（GI）器官接近。
我们有来自多个中心的数据表明，PBT 可以安全地提供高剂量的消融放射治疗，在治疗中具有良好的耐受性，同时能实现优异的局部控制效果。PBT 是一种有效的治疗方法，其疗效已得到长期证实，并且应用越来越广泛。
