湘南镰仓综合医院点扫描质子束治疗的相对生物学效应值。

Relative Biological Effectiveness Values of Spot-scanning Proton Beam Therapy at Shonan Kamakura General Hospital.

机构信息

Department of Radiation Oncology, Shonan Kamakura General Hospital, Kamakura, Japan;

Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Japan.

出版信息

In Vivo. 2023 May-Jun;37(3):1016-1021. doi: 10.21873/invivo.13175.

DOI:10.21873/invivo.13175

PMID:37103115

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10187997/

Abstract

BACKGROUND/AIM: This study aimed to confirm the relative biological effectiveness (RBE) values of the proton beam therapy (PBT) system installed in Shonan Kamakura General Hospital.

MATERIALS AND METHODS

Clonogenic cell-survival assays were performed with a human salivary gland (HSG) cell line, a human tongue squamous-cell carcinoma cell line (SAS), and a human osteosarcoma cell line (MG-63). Cells were irradiated with proton beams and X-rays with different doses (1.8, 3.6, 5.5, and 7.3 Gy for proton beams, and 2, 4, 6, and 8 Gy for X-rays). Proton beam irradiation used spot-scanning methods and three different depths (at the proximal, center, and distal sides of the spread-out Bragg peak). RBE values were obtained from a comparison of the dose that resulted in a surviving fraction of 10% (D).

RESULTS

D of proton beams at the proximal, center, and distal sides and X-rays in HSG were 4.71, 4.71, 4.51, and 5.25 Gy, respectively; those in SAS were 5.08, 5.04, 5.01, and 5.59 Gy, respectively; and those in MG-63 were 5.36, 5.42, 5.12, and 6.06 Gy, respectively. The RBE values at the proximal, center, and distal sides in HSG were 1.11, 1.11, and 1.16 respectively; those in SAS were 1.10, 1.11, and 1.12, respectively; and those in MG-63 were 1.13, 1.12, and 1.18, respectively.

CONCLUSION

RBE values of 1.10-1.18 were confirmed by in vitro experiments using the PBT system. These results are considered acceptable for clinical use in terms of therapeutic efficacy and safety.

摘要

背景/目的：本研究旨在确认安装在湘南镰仓综合医院的质子束治疗（PBT）系统的相对生物学效应（RBE）值。

材料和方法

采用人唾液腺（HSG）细胞系、人舌鳞癌细胞系（SAS）和人骨肉瘤细胞系（MG-63）进行集落形成细胞存活实验。用质子束和 X 射线以不同剂量照射细胞（质子束为 1.8、3.6、5.5 和 7.3 Gy，X 射线为 2、4、6 和 8 Gy）。质子束照射采用点扫描方法和三个不同深度（扩展布拉格峰的近端、中心和远端）。通过比较导致存活分数为 10%的剂量（D）获得 RBE 值。

结果

在 HSG 中，质子束在近端、中心和远端以及 X 射线的 D 值分别为 4.71、4.71、4.51 和 5.25 Gy；在 SAS 中，D 值分别为 5.08、5.04、5.01 和 5.59 Gy；在 MG-63 中，D 值分别为 5.36、5.42、5.12 和 6.06 Gy。在 HSG 中，质子束在近端、中心和远端的 RBE 值分别为 1.11、1.11 和 1.16；在 SAS 中，RBE 值分别为 1.10、1.11 和 1.12；在 MG-63 中，RBE 值分别为 1.13、1.12 和 1.18。