Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, Republic of Korea.
Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India.
J Med Virol. 2020 Jun;92(6):618-631. doi: 10.1002/jmv.25736. Epub 2020 Mar 5.
Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.
最近，一种新型冠状病毒（SARS-COV-2）在中国武汉爆发，该病毒是导致此次疫情的罪魁祸首。从遗传学角度来看，它与 SARS-CoV 和 MERS-CoV 密切相关。目前疫情形势日益严峻，因此，迫切需要设计针对 SARS-COV-2 的合适的肽疫苗成分。在这里，我们对刺突糖蛋白进行了特征分析，以获得免疫原性表位。接下来，我们选择了 13 个主要组织相容性复合体（MHC）I 和 3 个 MHC-II 表位，这些表位具有抗原性。这些表位通常与特定的接头相连，以构建疫苗成分，并与 Toll 样受体-5 进行分子对接，以获得结合亲和力。因此，为了提供这些表位的快速免疫原性特征，我们进行了免疫信息学分析，以便快速开发疫苗能够尽早结束这场灾难性的疫情。
