Seab J P, Jagust W J, Wong S T, Roos M S, Reed B R, Budinger T F
Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
Magn Reson Med. 1988 Oct;8(2):200-8. doi: 10.1002/mrm.1910080210.
Nuclear magnetic resonance (NMR) imaging was employed to study 10 patients with Alzheimer's disease (AD) and seven healthy elderly control subjects. Coronal sections were used to make volumetric measurements of the hippocampus, ventricles, subarachnoid space, and brain parenchyma. The hippocampal volume (normalized relative to the size of the lenticular nucleus) was reduced by 40% in the AD group compared to the controls, with no overlap between the two groups. Overall measures of brain atrophy and ventricular and sulcal enlargement also showed significantly different group means, although with overlap between the two groups. Hippocampal atrophy did not correlate with either overall brain atrophy or dementia severity, although the degree of brain atrophy was correlated with dementia severity. These results show that NMR is capable of providing in vivo quantification of diminished hippocampal size in AD which is not correlated with overall brain atrophy and which may differentiate AD from normal aging.
采用核磁共振（NMR）成像技术对10例阿尔茨海默病（AD）患者和7名健康老年对照者进行研究。使用冠状切面测量海马体、脑室、蛛网膜下腔和脑实质的体积。与对照组相比，AD组的海马体体积（相对于豆状核大小进行标准化）减少了40%，两组之间无重叠。脑萎缩以及脑室和脑沟扩大的总体测量结果也显示出两组的均值有显著差异，尽管两组之间存在重叠。海马体萎缩与整体脑萎缩或痴呆严重程度均无相关性，不过脑萎缩程度与痴呆严重程度相关。这些结果表明，NMR能够在体内对AD患者海马体缩小进行量化，这与整体脑萎缩无关，且可能有助于将AD与正常衰老区分开来。
