Yi Caixia, Yu Zhihai, Ren Qian, Liu Xian, Wang Yan, Sun Xin, Yin Shuanghong, Pan Jun, Huang Xiao
Institute of Nanomedicine and Biomaterials, School of Sports and Health Science, Tongren University, Tongren 554300, China.
Department of Urology Surgery, Three Gorges Central Hospital, Chongqing 404000, China.
Photodiagnosis Photodyn Ther. 2020 Jun;30:101694. doi: 10.1016/j.pdpdt.2020.101694. Epub 2020 Feb 25.
Due to the ability to induce the generation of reactive oxygen species (ROS) under light irradiation, ZnO nanoparticles show great potential in photodynamic therapy (PDT). Photo-triggered ROS production by ZnO nanoparticles and the resulting phototoxicity are efficient in killing cancer cells. This review highlights the recent exciting progress on the nanoscale ZnO-based photosensitizers (PSs) for PDT. Both the semplice ZnO nanoparticles as the PSs and the various chemicals (organic PS, dopant, metal and chemotherapeutic drugs) modified ZnO nanoparticles as the PSs show good ROS generation efficiency. The productive rate of ROS, the wavelength of exciting lights, and the therapeutic effect can be altered by doping different chemicals into ZnO nanoparticles at will. Additionally, we give some outlook on the design and functionalization of next-generation ZnO nanoparticles for more effective anti-cancer applications.
由于在光照射下能够诱导活性氧（ROS）的产生，氧化锌纳米颗粒在光动力疗法（PDT）中显示出巨大潜力。氧化锌纳米颗粒光触发产生ROS以及由此产生的光毒性对杀死癌细胞非常有效。本文综述了基于纳米级氧化锌的光动力疗法光敏剂（PSs）的最新研究进展。单纯的氧化锌纳米颗粒作为PSs以及各种化学物质（有机PS、掺杂剂、金属和化疗药物）修饰的氧化锌纳米颗粒作为PSs都显示出良好的ROS产生效率。通过随意向氧化锌纳米颗粒中掺杂不同的化学物质，可以改变ROS的产生速率、激发光的波长以及治疗效果。此外，我们对下一代氧化锌纳米颗粒的设计和功能化进行了展望，以期实现更有效的抗癌应用。
