Yang Meng, Yang Wenhua, Chen Liang, Ding Mingjian, Li Chenhao, Shi Dongliang
The Second Department of Thyroid and Breast Surgery, Cangzhou Central Hospital, Cangzhou, China.
Dose Response. 2020 Feb 17;18(1):1559325820906662. doi: 10.1177/1559325820906662. eCollection 2020 Jan-Mar.
Doxorubicin (DOX) alone or in combination has been widely used for numerous cancers, including breast, lung, bladder, and so on. In this article, a core/shell/shell structured FeO@SiO@Au@porous SiO particles for the drug delivery and release of DOX was demonstrated, with the aid of near-infrared irradiation. FeO was used to direct the transportation and delivery of the drug-loaded composite to the target tissues and organs under an external magnetic field, the first layer of SiO was used for Au nanoparticle attachment, Au acted as the agent for light-thermal conversion, and the porous SiO was used to load DOX. The morphology of the nanoparticles was studied by transmission electron microscopy, and the porous structure was characterized by N adsorption/desorption curves. The drug delivery system displayed high drug loading capacity, and the release behavior was largely impacted by the environmental pH. Furthermore, the cytotoxicity of FeO@SiO@Au@porous SiO and DOX loaded FeO@SiO@Au@porous SiO was studied through in vitro 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cell viability assay.
阿霉素（DOX）单独使用或联合使用已被广泛应用于多种癌症，包括乳腺癌、肺癌、膀胱癌等。在本文中，展示了一种核/壳/壳结构的FeO@SiO@Au@多孔SiO颗粒用于阿霉素的药物递送和释放，借助近红外辐射。FeO用于在外部磁场下将载药复合物运输并递送至靶组织和器官，第一层SiO用于附着金纳米颗粒，金作为光热转换剂，多孔SiO用于负载阿霉素。通过透射电子显微镜研究了纳米颗粒的形态，并通过N吸附/解吸曲线对多孔结构进行了表征。该药物递送系统显示出高载药能力，且释放行为在很大程度上受环境pH的影响。此外，通过体外3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐细胞活力测定法研究了FeO@SiO@Au@多孔SiO和负载阿霉素的FeO@SiO@Au@多孔SiO的细胞毒性。
