College of Pharmaceutical Sciences, Jiangsu University, Zhenjiang, Jiangsu 212013, China.
J Mater Chem B. 2019 Feb 21;7(7):1096-1106. doi: 10.1039/c8tb02684j. Epub 2019 Jan 25.
The targeted delivery of anticancer drugs for improving the therapeutic efficacy and reducing the side effects has attracted great attention in cancer therapy. In this study, multifunctional magnetic nanoparticles-loaded thermosensitive liposomes (FeO-TSL) were developed for the near-infrared (NIR) laser-triggered release and combined photothermal-chemotherapy of tumors. Doxorubicin (DOX) was encapsulated into the FeO-TSL (DOX-FeO-TSL) via an ammonium sulfate gradient, with an encapsulation efficiency of up to 90.9%. Once treated with NIR laser irradiation, significantly improved drug release was observed in the DOX-FeO-TSL compared to that of DOX-TSL. After an intravenous injection, FeO-TSL tended to enrich in the tumor over time and showed remarkable magnetic resonance imaging (MRI) and photothermal effects. The combined chemo-photothermal therapy study demonstrated that DOX-FeO-TSL could significantly inhibit the tumor growth without causing any significant damage to normal tissues under NIR laser irradiation. These results revealed a great potential for DOX-FeO-TSL for the diagnosis and synergistic therapy of tumors.
靶向递抗癌药物以提高治疗效果和降低副作用在癌症治疗中引起了极大关注。在本研究中，开发了负载多功能磁性纳米粒子的热敏脂质体（FeO-TSL），用于近红外（NIR）激光触发释放和肿瘤的光热化疗联合治疗。阿霉素（DOX）通过硫酸铵梯度包封到 FeO-TSL（DOX-FeO-TSL）中，包封效率高达 90.9%。一旦用 NIR 激光照射，与 DOX-TSL 相比，DOX-FeO-TSL 中观察到明显改善的药物释放。静脉注射后，FeO-TSL 随着时间的推移倾向于在肿瘤中富集，并表现出显著的磁共振成像（MRI）和光热效应。联合化疗-光热治疗研究表明，在 NIR 激光照射下，DOX-FeO-TSL 可显著抑制肿瘤生长，而不会对正常组织造成任何明显损伤。这些结果表明 DOX-FeO-TSL 在肿瘤的诊断和协同治疗方面具有巨大潜力。
