Mohamed Shehab F, Qatami Ahmed, Nashwan Abdulqadir, Abdulla Mohammad A, Yassin Mohamed A
Hematology, Medical Oncology Section, National Center for Cancer Care and Research, Hamad Medical Corporation (HMC), Doha, Qatar.
Ophthalmology Department, Hamad Medical Corporation (HMC), Doha, Qatar.
Case Rep Oncol. 2020 Jan 20;13(1):7-11. doi: 10.1159/000504928. eCollection 2020 Jan-Apr.
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm, classically described as triphasic disease (chronic, accelerated, and blast). Despite the significant efforts made by different groups to optimize treatment and outcome, there are still unmet needs and unanswered questions. Ophthalmologic manifestations are among the therapeutic challenges. The best available therapy for patients presenting with ophthalmologic manifestations is still unclear. Here we present two cases of CML (chronic phase) with ophthalmologic manifestations as initial presentation, trying to shed light on this important type of presentation and proposing recommendations for hematologists in view of the current literature.
慢性髓性白血病（CML）是一种骨髓增殖性肿瘤，传统上被描述为三相性疾病（慢性期、加速期和急变期）。尽管不同团队为优化治疗和改善预后做出了巨大努力，但仍存在未满足的需求和未解答的问题。眼科表现是治疗挑战之一。对于出现眼科表现的患者，目前最佳的治疗方法仍不明确。在此，我们报告两例以眼科表现为首发症状的慢性期CML病例，旨在阐明这种重要的首发类型，并根据当前文献为血液科医生提出建议。
