一种无过渡金属且无重氮的苯乙烯环丙烷化反应。
A transition-metal-free & diazo-free styrene cyclopropanation.
作者信息
Herraiz Ana G, Suero Marcos G
机构信息
Institute of Chemical Research of Catalonia (ICIQ) , The Barcelona Institute of Science and Technology , Av. Països Catalans 16 , Tarragona , 43007 , Spain . Email:
Departament de Química Analítica i Química Orgànica , Universitat Rovira i Virgili , Calle Marcel. lí Domingo, 1 , Tarragona , 43007 , Spain.
出版信息
Chem Sci. 2019 Aug 28;10(40):9374-9379. doi: 10.1039/c9sc02749a. eCollection 2019 Oct 28.
An operationally simple and broadly applicable novel cyclopropanation of styrenes using -diiodomethyl carbonyl reagents has been developed. Visible-light triggered the photoinduced generation of iodomethyl carbonyl radicals, able to cyclopropanate a wide array of styrenes with excellent chemoselectivity and functional group tolerance. To highlight the utility of our photocyclopropanation, we demonstrated the late-stage functionalization of biomolecule derivatives.
已开发出一种操作简单且广泛适用的新型方法，使用 -二碘甲基羰基试剂对苯乙烯进行环丙烷化反应。可见光引发碘甲基羰基自由基的光致生成，该自由基能够以优异的化学选择性和官能团耐受性使多种苯乙烯发生环丙烷化反应。为突出我们的光环丙烷化反应的实用性，我们展示了生物分子衍生物的后期官能团化反应。
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