Makri Nikoleta, Paterson Gavin K, Gregge Fiona, Urquhart Catriona, Nuttall Tim
Dermatology Service, Hospital for Small Animals, University of Edinburgh, Royal (Dick) School of Veterinary Studies, Roslin, UK.
Easter Bush Pathology, University of Edinburgh, Royal (Dick) School of Veterinary Studies, Roslin, UK.
JFMS Open Rep. 2020 Feb 14;6(1):2055116920906001. doi: 10.1177/2055116920906001. eCollection 2020 Jan-Jun.
A 12-year-old female neutered indoor-outdoor domestic longhair cat presented with frequent sneezing and a nodular, suppurative lesion on its dorsal nose. Histopathological examination revealed a fungal granuloma. PCR and sequencing of the ribosomal internal transcribed spacers (ITS) regions (ITS-F and ITS-R) confirmed an infection with a species. Further sequencing of the beta-tubulin and calmodulin genes confirmed , which lies within the complex. The cat had concurrent diabetes mellitus, which responded to insulin therapy and diet. Oral itraconazole at 10 mg/kg PO q24h resulted in resolution of the lesions after 12 months. Treatment was well tolerated.
This is the first report of sporotrichosis in a cat in the UK and only the fifth worldwide involving the complex. Clinicians, pathologists and microbiologists need to be aware of the potential of infections in the UK and the ability of complex to cause opportunistic infections. Molecular techniques can achieve rapid and accurate identification of rare fungal organisms. A precise diagnosis with molecular testing can provide information regarding prognosis, treatment and zoonotic implications.
一只12岁已绝育的室内外活动的家养长毛雌性猫，出现频繁打喷嚏，其鼻背部有一个结节性化脓性病变。组织病理学检查显示为真菌性肉芽肿。对核糖体内部转录间隔区（ITS）区域（ITS-F和ITS-R）进行聚合酶链反应（PCR）和测序，证实感染了一种 菌。对β-微管蛋白和钙调蛋白基因进行进一步测序，证实为 菌，它属于 复合体。这只猫同时患有糖尿病，对胰岛素治疗和饮食调整有反应。口服伊曲康唑，剂量为10 mg/kg，每日一次，12个月后病变消退。治疗耐受性良好。
这是英国首例猫孢子丝菌病报告，也是全球第五例涉及 复合体的病例。临床医生、病理学家和微生物学家需要意识到英国存在 菌感染的可能性，以及 复合体导致机会性感染的能力。分子技术能够快速准确地鉴定罕见真菌病原体。通过分子检测进行精确诊断可以提供有关预后、治疗和人畜共患病影响的信息。
