血液透析患者血清脂联素水平与外周动脉闭塞性疾病的负相关性。
Negative correlation of serum adiponectin level with peripheral artery occlusive disease in hemodialysis patients.
作者信息
Lai Yu-Hsien, Lin Yu-Li, Wang Chih-Hsien, Kuo Chiu-Huang, Hsu Bang-Gee
机构信息
Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
PhD Program in Pharmacology and Toxicology, Tzu Chi University, Hualien, Taiwan.
出版信息
Tzu Chi Med J. 2019 Apr 2;32(1):70-74. doi: 10.4103/tcmj.tcmj_19_19. eCollection 2020 Jan-Mar.
OBJECTIVE
Adiponectin is a fat-derived hormone that secretes exclusively by adipocytes and has antiatherosclerotic effects. Peripheral arterial occlusive disease (PAOD) is associated with an increased risk of death in hemodialysis (HD) patients. The aim of this study was to evaluate the relationship between serum adiponectin levels and PAOD by ankle-brachial index (ABI) in HD patients.
MATERIALS AND METHODS
Blood samples were obtained from 100 HD patients. Serum adiponectin levels were measured using a commercial enzyme-linked immunosorbent assay kit. ABI values were measured using the automated oscillometric method (VaSera VS-1000). ABI values that <0.9 were included in the low ABI group.
RESULTS
Among the 100 HD patients, 18 of them (18.0%) were in the low ABI group. Compared with patients in the normal ABI group, the patients in the low ABI group had a higher prevalence of diabetes ( = 0.043), older age ( = 0.027), and lower serum adiponectin level ( = 0.003). In addition, the multivariable logistic regression analysis showed that adiponectin (Odds ratio [OR]: 0.927, 95% confidence interval [CI]: 0.867-0.990, = 0.025) and age (OR: 1.054, 95% CI: 1.002-1.109, = 0.043) were the independently associated with PAOD in HD patients.
CONCLUSION
In this study, serum adiponectin level was found to be associated with PAOD in HD patients.
目的
脂联素是一种仅由脂肪细胞分泌的脂肪衍生激素，具有抗动脉粥样硬化作用。外周动脉闭塞性疾病（PAOD）与血液透析（HD）患者的死亡风险增加相关。本研究旨在通过踝臂指数（ABI）评估HD患者血清脂联素水平与PAOD之间的关系。
材料与方法
从100例HD患者中采集血样。使用商业酶联免疫吸附测定试剂盒测量血清脂联素水平。使用自动示波法（VaSera VS - 1000）测量ABI值。ABI值<0.9的患者纳入低ABI组。
结果
在100例HD患者中，18例（18.0%）属于低ABI组。与正常ABI组患者相比，低ABI组患者糖尿病患病率更高（P = 0.043）、年龄更大（P = 0.027）且血清脂联素水平更低（P = 0.003）。此外，多变量逻辑回归分析显示，脂联素（比值比[OR]：0.927，95%置信区间[CI]：0.867 - 0.990，P = 0.025）和年龄（OR：1.054，95%CI：1.002 - 1.109，P = 0.043）与HD患者的PAOD独立相关。
结论
在本研究中，发现HD患者血清脂联素水平与PAOD相关。
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