Chiu Liang-Te, Hsu Bang-Gee, Lai Yu-Hsien, Wang Chih-Hsien, Tsai Jen-Pi
Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 62247 Chiayi, Taiwan.
Division of Nephrology, Department of Internal Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, 97010 Hualien, Taiwan.
Rev Cardiovasc Med. 2024 Mar 29;25(4):124. doi: 10.31083/j.rcm2504124. eCollection 2024 Apr.
Galectin-3 is implicated in the pathogenesis of inflammation and atherosclerosis. Peripheral arterial disease (PAD), characterized by a reduced ankle-brachial index (ABI), is a prognostic marker for mortality in patients on hemodialysis. We investigated the relationship between serum galectin-3 levels and PAD in patients undergoing regular hemodialysis.
We carried out a cross-sectional study at a medical center, involving 92 participants. Serum galectin-3 levels were assessed by a commercially available enzyme-linked immunosorbent assay. ABI measurement was done with an automatic device based on oscillometry. Participants were categorized into two groups, normal and low ABI, based on a 0.9 cut-off point.
Eighteen patients (19.6%) exhibited a low ABI. In individuals with low ABIs, we observed a greater prevalence of diabetes mellitus, elevated serum C-reactive protein (CRP) levels, increased galectin-3 levels, and lower serum creatinine levels. Furthermore, serum galectin-3 levels (odds ratio [OR]: 1.056, 95% confidence interval [CI]: 1.003-1.112, = 0.037) and CRP (per 0.1 mg/dL increment, OR: 1.195, 95% CI: 1.032-1.383, = 0.017) were identified as independent predictors of PAD. Serum galectin-3 and log-transformed CRP levels were also independently and significantly negatively correlated with the left and right ABI values.
Serum galectin-3 levels correlate with PAD in patients undergoing maintenance hemodialysis.
半乳糖凝集素-3与炎症和动脉粥样硬化的发病机制有关。外周动脉疾病（PAD）以踝臂指数（ABI）降低为特征，是血液透析患者死亡率的一个预后指标。我们研究了定期血液透析患者血清半乳糖凝集素-3水平与PAD之间的关系。
我们在一家医疗中心进行了一项横断面研究，涉及92名参与者。血清半乳糖凝集素-3水平通过市售的酶联免疫吸附测定法进行评估。ABI测量使用基于示波法的自动设备进行。根据0.9的截断点，参与者被分为两组，即正常ABI组和低ABI组。
18名患者（19.6%）表现出低ABI。在低ABI个体中，我们观察到糖尿病患病率更高、血清C反应蛋白（CRP）水平升高、半乳糖凝集素-3水平升高以及血清肌酐水平降低。此外，血清半乳糖凝集素-3水平（比值比[OR]：1.056，95%置信区间[CI]：1.003 - 1.112，P = 0.037）和CRP（每增加0.1 mg/dL，OR：1.195，95% CI：1.032 - 1.383，P = 0.017）被确定为PAD的独立预测因素。血清半乳糖凝集素-3和经对数转换的CRP水平也与左右ABI值独立且显著负相关。
维持性血液透析患者的血清半乳糖凝集素-3水平与PAD相关。
