Buhagiar Alfred, Borg Joseph, Ayers Duncan
Faculty of Medicine and Surgery, University of Malta, Msida, MSD 2080, Malta.
Faculty of Health Sciences, University of Malta, Msida, MSD 2080, Malta.
Noncoding RNA Res. 2020 Feb 19;5(1):22-26. doi: 10.1016/j.ncrna.2020.02.001. eCollection 2020 Mar.
Haematological malignancies encompass all variations of leukaemia at both the chronic and acute level, together with the specific cell type induced into tumourigenesis. Current diagnostic protocols for leukaemic conditions rely heavily on cytomorphology and other histological examinations from bone marrow aspirates, with the latter being a highly invasive surgical procedure for the patient. The discovery of microRNAs as one of the key gene regulatory networks in the past two decades has enabled researchers to investigate the possibility of exploiting the identification of dysregulated expression profiles for specific microRNAs present in the leukaemic patient's bloodstream as novel liquid biopsy diagnostic tools. This review article serves to consolidate recent global research efforts aiming to achieve such scopes.
血液系统恶性肿瘤包括慢性和急性白血病的所有变体，以及引发肿瘤形成的特定细胞类型。目前白血病的诊断方案严重依赖于骨髓穿刺液的细胞形态学和其他组织学检查，而后者对患者来说是一种侵入性很强的外科手术。在过去二十年中，作为关键基因调控网络之一的微小RNA的发现，使研究人员能够探索利用白血病患者血液中特定微小RNA表达谱失调的鉴定作为新型液体活检诊断工具的可能性。这篇综述文章旨在整合近期全球旨在实现此类目标的研究工作。
