Chemistry Department, Polymer Research Group, Faculty of Science, University of Tanta, Tanta 31527, Egypt.
Polymeric Materials Research Department, Advanced Technology and New Materials Research Institute (ATNMRI), City of Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P.O. Box, 21934, Alexandria, Egypt.
Int J Biol Macromol. 2019 Oct 15;139:440-448. doi: 10.1016/j.ijbiomac.2019.07.191. Epub 2019 Jul 29.
This study intends to fabricate new biodegradable and antimicrobial membranes based on crosslinked gelatin/chitosan biopolymers. Cinnamaldehyde was incorporated into membranes for boosting their antimicrobial activities. FTIR spectroscopy and electronic spectrum analysis were used to prove their chemical structures, while SEM and TGA analysis were applied to investigate the morphological changes and the thermal properties of the crosslinked membranes. Moreover, ion exchange capacity, wettability and mechanical analysis were also conducted to get more information about the physicochemical properties for the developed membranes. Four different types of bacteria have been used for studying the antibacterial activities of the crosslinked membranes (one gram-positive and three gram-negative bacteria). The results showed a significant augmentation in the inhibition percent with increasing cinnamaldehyde content in the membrane matrix. Besides, hemocompatibility, biodegradability, and cytotoxicity studies were performed and the findings emphasized that the as-fabricated biodegradable gelatin/chitosan/cinnamaldehyde membranes could be efficiently used as antibacterial dressers for ameliorating the wound healing.
本研究旨在制备基于交联明胶/壳聚糖生物聚合物的新型可生物降解和抗菌膜。肉桂醛被掺入膜中以提高其抗菌活性。傅里叶变换红外光谱和电子能谱分析用于证明它们的化学结构，而扫描电子显微镜和热重分析用于研究交联膜的形态变化和热性能。此外，还进行了离子交换容量、润湿性和机械分析，以获取有关开发膜的物理化学性质的更多信息。使用了四种不同类型的细菌来研究交联膜的抗菌活性（一种革兰氏阳性菌和三种革兰氏阴性菌）。结果表明，随着膜基质中肉桂醛含量的增加，抑制率显著增加。此外，还进行了血液相容性、生物降解性和细胞毒性研究，研究结果强调，所制备的可生物降解的明胶/壳聚糖/肉桂醛膜可以有效地用作抗菌敷料，以改善伤口愈合。
