Department of Pathology, Xiangya Hospital, Central South UniversityChangshaP.R. China.
Department of Pharmacy, Xiangya Hospital, Central South UniversityChangshaP.R. China.
Oncol Res. 2020 Sep 1;28(4):439-446. doi: 10.3727/096504020X15828892654385. Epub 2020 Feb 28.
Natural products are becoming increasingly popular in a variety of traditional, complementary, and alternative systems due to their potency and slight side effects. Natural compounds have been shown to be effective against many human diseases, especially cancers. Sulforaphane (SFE) is a traditional Chinese herbal medicine. In recent years, an increasing number of studies have been conducted to evaluate the antitumor effect of SFE. The roles of SFE in cancers are mainly through the regulation of potential biomarkers to activate or inhibit related signaling pathways. SFE has exhibited promising inhibitory effects on breast cancer, lung cancer, liver cancer, and other malignant tumors. In this review, we summarized the reports on the activity and functional mechanisms of SFE in cancer treatment and explored the efficacy and toxicity of SFE.
天然产物因其疗效和轻微的副作用，在各种传统、补充和替代系统中越来越受欢迎。天然化合物已被证明对许多人类疾病有效，尤其是癌症。萝卜硫素（SFE）是一种传统的中草药。近年来，越来越多的研究评估 SFE 的抗肿瘤作用。SFE 在癌症中的作用主要是通过调节潜在的生物标志物来激活或抑制相关的信号通路。SFE 对乳腺癌、肺癌、肝癌等恶性肿瘤表现出有希望的抑制作用。在这篇综述中，我们总结了 SFE 在癌症治疗中的活性和功能机制的报告，并探讨了 SFE 的疗效和毒性。
