Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Ultrasound Med Biol. 2020 May;46(5):1263-1269. doi: 10.1016/j.ultrasmedbio.2020.01.021. Epub 2020 Feb 25.
Scleroderma, or systemic sclerosis (SSc), is a multi-organ connective tissue disease characterized by immune dysregulation and tissue fibrosis. Skin disease is both a disabling feature of SSc and a predictor of visceral involvement and increased mortality. The Modified Rodnan Skin Score (MRSS) is currently the most common clinical method for assessing skin. We developed ultrasound surface wave elastography (USWE) techniques to measure skin surface wave speeds and analyze skin viscoelasticity. The objective of this research was to determine the correlations of skin surface wave speed and skin viscoelasticity with MRSS. Twenty-six SSc patients were studied using USWE and the MRSS. The subject was tested in a sitting position while his or her left or right forearm and upper arm were placed horizontally on a pillow in a relaxed state. The skin of both left and right forearms and upper arms of patients was tested using USWE. Surface wave speeds are positively correlated with the MRSS. Skin elasticity is also positively correlated with the MRSS. However, there was no correlation between skin viscosity and the MRSS for these SSc patients. We will further study if skin viscosity is sensitive enough to detect early edema from inflammation changes of SSc.
硬皮病，又称系统性硬化症（SSc），是一种以免疫失调和组织纤维化为特征的多器官结缔组织疾病。皮肤疾病既是 SSc 的致残特征，也是内脏受累和死亡率增加的预测因素。改良罗德里纳皮肤评分（MRSS）是目前评估皮肤最常用的临床方法。我们开发了超声表面波弹性成像（USWE）技术来测量皮肤表面波速度并分析皮肤粘弹性。本研究的目的是确定皮肤表面波速度和皮肤粘弹性与 MRSS 的相关性。对 26 例 SSc 患者进行了 USWE 和 MRSS 检查。受检者取坐位，将其左右前臂和上臂水平置于枕头上面，处于放松状态。使用 USWE 检测患者左右前臂和上臂的皮肤。表面波速度与 MRSS 呈正相关。皮肤弹性也与 MRSS 呈正相关。然而，对于这些 SSc 患者，皮肤粘度与 MRSS 之间没有相关性。我们将进一步研究皮肤粘度是否足够敏感以检测 SSc 炎症变化引起的早期水肿。
