The School of Nursing, Fujian Medical University, Fuzhou, Fujian Province, China.
Department of surgical oncology of abdomen, Fujian Cancer Hospital, the Affiliated Cancer Hospital of Fujian Medical University, Fuzhou, Fujian Province, China.
Arch Med Res. 2020 Feb;51(2):173-179. doi: 10.1016/j.arcmed.2019.12.015. Epub 2020 Feb 26.
Exercise can be beneficial for patients with colorectal cancer; however, few studies have evaluated the effect of exercise on cancer-related fatigue and quality of life.
To assess the efficacy of physical exercise for patients with colorectal cancer during treatment, we conducted a meta-analysis of randomized controlled trials.
Databases, including PubMed, Ovid, Embase, the Cochrane Central Register of Controlled Trials, and the China National Knowledge Infrastructure database were searched to identify suitable studies. Stata 12.0 was used for statistical analysis, and sensitivity analysis was conducted. Nine, five, three, and five studies included data that could be evaluated to assess the effects of physical exercise on cancer-related fatigue, cognitive factors, social factors, and physical factors, respectively, in patients with colorectal cancer during treatment. Ten studies, including 934 patients, were selected for meta-analysis, including five each published in the English and Chinese languages.
Significant effects of exercise were detected for cancer-related fatigue (standardized mean difference (SMD) = -1.34, p <0.001) and social factors (SMD = 0.67, p = 0.012). Moderate intensity exercise and exercise for less than 12 weeks were identified as effective for preventing cancer-related fatigue. Further, exercise can also improve the level of social support experienced by patients; however, our data indicate that exercise has no significant effect on cognitive or physiological factors.
Medium intensity exercise can effectively reduce cancer-related fatigue and improve the quality of life of patients with colorectal cancer.
运动对结直肠癌患者有益；然而，很少有研究评估运动对癌症相关疲劳和生活质量的影响。
我们对随机对照试验进行荟萃分析，评估治疗期间运动对结直肠癌患者的疗效。
检索了 PubMed、Ovid、Embase、Cochrane 中央对照试验注册库和中国国家知识基础设施数据库等数据库，以确定合适的研究。使用 Stata 12.0 进行统计分析，并进行敏感性分析。9 项、5 项、3 项和 5 项研究分别纳入了可评估运动对治疗期间结直肠癌患者癌症相关疲劳、认知因素、社会因素和身体因素影响的数据。纳入了 10 项研究，共 934 名患者，包括英文和中文各 5 项研究，进行荟萃分析。
运动对癌症相关疲劳（标准化均数差（SMD）=-1.34，p<0.001）和社会因素（SMD=0.67，p=0.012）有显著效果。中等强度运动和运动时间小于 12 周被认为能有效预防癌症相关疲劳。此外，运动还可以提高患者所获得的社会支持水平；然而，我们的数据表明，运动对认知或生理因素没有显著影响。
中等强度运动可以有效减轻癌症相关疲劳，提高结直肠癌患者的生活质量。
